肠癌患者Cyfra21-1与临床病理参数关系回顾性分析

目的 Cyffa21-1是常见的血清肿瘤标志物之一,但其在肠癌中的研究较少.本研究旨在分析肠癌患者术前Cyfra21-1水平和临床病理参数的关系.方法 收集解放军总医院海南分院2012-06-01-2016-06-01经病理确诊的肠癌患者115例,将患者性别、年龄、肿瘤位置、肿瘤细胞分化程度、TNM分期、微卫星状态、Ki-67指数和危险因素等与Cy-fra21-1、CEA水平进行统计分析.结果 术前Cyfra21-1和CEA的阳性率分别为38.26％(44/115)和37.39％(43/115),双阳性和仅Cyfra21-1的阳性率均为19.13％(22/115),仅CEA阳性率为18.26％(21/115),双阴性率43.47％(50/115).术前Cyfra21-1水平在不同的肿瘤细胞分化程度(x2=14.47,P＜0.001)和M分期(x2=4.62,P=0.03)中差异有统计学意义,而术前CEA水平在不同的T(x2=17.72,P=0.00)、M(x2=7.81,P＜0.001)及TNM分期(x2 =19.26,P＜0.001)差异有统计学意义.肿瘤最大径及阳性淋巴结数在两者升高组中均对应升高,均P＜0.05.Lo-gistic多因素回归分析提示,对术前Cyfra21-1水平存在重要影响因素的是肿瘤细胞分化程度和肿瘤最大径;相对于低分化,中分化OR=0.17,95％CI为0.04～0.69,P=0.01;高分化OR=0.06,95％CI为0.00～0.78,P=0.03.结论 术前Cyfra21-1水平在肠癌患者中具有较高的阳性率,可能对判断肿瘤细胞分化程度、肿瘤侵犯范围等提供一定帮助.

Correlation of CYFRA21-1 with the clinicopathological parameters in colorectal cancer patients : A retrospective study

OBJECTIVE Cyfra21-1 is one of the conventional tumor markers but its role in colorectal cancer are still largely unknown.The present study aimed to investigate the correlation between the value of preoperative Cyfra21-1 and the clinicopathological parameters in colorectal cancer patients.METHODS Totally 115 pathologically confirmed validated cases from June 1,2012 to 2016 were collected in our hospital,parameters including gender,age,tumor location,cancer cell differentiation,TNM stage,microsatellite state,Ki-67 index,risk factors and the value of Cyfra21-1,CEA were recorded and further statistical analysis were performed.RESULTS Positive rate of preoperative Cyfra21-1 and CEA was 38.26％(44/115) and 37.39％ (43/115),respectively.Double positive and only Cyfra21-1 positive rate was 19.13％(22/115),sole CEA positive rate was 18.26％ (21/115),whereas double negative rate was 43.47％ (50/115).Value of preoperative Cyfra21-1 presented significant statistical differences in different cancer cell differentiation (x2 =14.47,P＜0.001) and M stage (x2 =4.62,P-0.03),and preoperative CEA value shown similar differences in different T (x2 =17.72,P =0.00),M (x2 =7.81,P =0.00) and TNM stages (x2 =19.26,P＜0.001),both the max tumor diameter and number of positive lymph nodes were obviously elevated in Cyfra21-1 and CEA increased patients (all P＜0.05).Cancer cell differentiation was found to be the most significant factors that could affect Cyfra 21-1 by Logistic regression analysis (with respect to low differentiation,moderate OR:0.17,95 ％ CI:0.04-0.69,P =0.01;high OR:0.06,95 ％ CI:0.00-0.78,P=0.03).CONCLUSION Preoperative Cyfra21-1 has a relatively high positive rate in colorectal cancer patients and it would be helpful in estimating cancer cell differentiation and invasive range.