三阴性乳腺癌化疗后前瞻性记忆损害特征分析

目的 有关不同分子分型的乳腺癌患者化疗后前瞻性记忆(prospective memory,PM)损害是否存在差异,目前尚不清楚.本研究探讨三阴性乳腺癌(triple negative breast cancer,TNBC)患者化疗后基于事件的PM(event-based prospective memory,EBPM)与基于时间的PM(time-based prospective memory,TBPM)损害特征.方法 收集2013-01-01-2015-09-30安徽医科大学第二附属医院肿瘤中心接受化疗的乳腺癌化疗后患者244例.其中TNBC 80例,非三阴性乳腺癌(non-triple negative breast cancer,NTNBC) 164例.建立EBPM与TBPM的认知神经心理学试验范式,分别进行化疗前后的PM测查.结果 与NTNBC患者相比,TNBC患者化疗后EBPM得分0.89±0.86,明显低于NTNBC组的2.59±0.90,差异有统计学意义,Z=-10.61,P＜0.01;TNBC和NTNBC患者化疗后TBPM得分别为4.65±0.83和4.80±0.92,差异无统计学意义,Z=-1.48,P＞0.05.结论 乳腺癌患者化疗后存在不同程度的PM障碍,且TN-BC较NTNBC患者EBPM损害更为显著.

Chemotherapy-induced event-based and time-based prospective memory impairment in triple negative breast cancer patients

OBJECTIVE It is not known whether chemotherapy-induced prospective memory (PM) impairment on different molecular classification of breast cancer patients exist difference.The aim of this study is to investigate the characteristics of chemotherapy-induced event-based prospective memory (EBPM) and time-based prospective memory (TB-PM) impairment in triple negative breast cancer (TNBC) patients.METHODS A total of 244 breast cancer patients who were hospitalized from January 2013 to September 2015 in the Department of Oncology at the Second Affiliated Hospital of Anhui Medical University were recruited.Eighty TNBC survivors and 164 non-triple negative breast cancer (NTNBC) survivors were respectively administered with PM tasks before and after chemotherapy.RESULTS Compared with NTNBC patients after chemotherapy,the EBPM score of TNBC patients was 0.89±0.86,obviously lower than that of NTNBC group (2.59 ± 0.90),exhibited statistical significance difference (Z =-10.61,P＜ 0.01).The TBPM score of TNBC and NTNBC patients after chemotherapy were 4.65± 0.83 and 4.80 ±0.92,had no statistical significance (Z=-1.48,P＞0.05).CONCLUSIONS There are different degrees of chemotherapy-induced prospective memory impairment in breast cancer patients,and the impairment of EBPM of TNBC is worse than that in NTNBC patients.