XIAP与Apaf-1在鼻内翻性乳头状瘤癌变中的表达及意义

目的探讨x-连锁凋亡抑制蛋白（XIAP）与凋亡蛋白酶活化因子-1（Apaf-1）在鼻内翻性乳头状瘤（NIP）发生发展及其恶变过程中的作用。方法采用兔抗人XIAP多克隆抗体和兔抗人Apaf-1多克隆抗体，应用免疫组化方法检测15例NIP伴癌变组织中XIAP与Apaf-1的表达。结果（1）XIAP在NIP、NIP伴癌变、NSCC中的表达结果分别为56％、86．6％、90％，差异有统计学意义（P〈0．05）；（2）Apaf-1在NIP、NIP伴癌变、NSCC中表达结果分别为60％、6．6％、20％，差异有统计学意义（P〈0．05）。结论检测XIAP与Apab1可作为判断NIP是否发生恶变的重要指标。

Expression and significance of XIAP and Apaf 1 in the carcinogenesis of nasal inverted papilloma

Objective To explore the expression of X-linked inhibitor apoptosis protein （XIAP） and apoptosis protease activating factor-1 Apaf-1 ） in nasal inverted papilloma （NIP）, and explore their function in the development and malignant change process of NIP. Methods Immunohistochemical method was used to detect the expressions of XIAP and Apaf 1 in 15 samples of the NIP with carcinomatous tissue. Results （1）The positive rate of XIAP protein expression was respectively 86.6%,56% and 90% in NIP, NIP with carcinomatous and NSCC, which was significantly deviated （P〈0.05）. （2）The positive rate of Apaf 1 protein expression was respectively 60% ,6.6% and 20% in NIP, NIP with carcinomatous and NSCC, which was significantly deviated （P〈0.05）. Conclusions The deteetion of XIAP and Apaf 1 may be an important indicator for judging NIPs malignant change or not.