FLEEOX新辅助化疗对进展期胃癌患者营养状况的影响

目的 研究FLEEOX新辅助化疗方案对进展期胃癌患者营养状况的影响.方法 根据纳入和排除标准,共选择2010年12月至2011年10月期间我科收治的难以手术切除并进行了新辅助化疗的48例胃癌患者,利用机体组成分析仪测定化疗前、后机体组成成分的变化,同时检测血液相关营养学指标.结果 患者化疗后,体重、细胞内液、体重指数、蛋白质、体脂肪、体细胞群及上臂周长均较化疗前表现为略下降,而细胞外液、身体水分含量、无机盐、骨骼矿物质含量、非脂群、骨骼肌及上臂无脂肪周长较化疗前均表现为略轻度上升,但各项指标差异均无统计学意义(P＞0.05)；血液中白蛋白、前白蛋白、总蛋白、转铁蛋白及淋巴细胞均较化疗前出现不同程度下降,但差异均无统计学意义(P＞0.05).结论 进展期胃癌患者接受化疗期间营养状况无明显变化,FLEEOX新辅助化疗未加重患者营养不良的状况.

Impact of Neoadjuvant FLEEOX Chemotherapy on Nutritional Status in Patients with Advanced Gastric Cancer

Objective To investigate the effect of FLEEOX regiment on nutritional status of advanced gastric cancer patients after neoadjuvant chemotherapy.MethodsForty-eight cases of advanced gastric cancer patients from December 2010 to October 2011 in this hospital were included into.The indexes of body composition and the blood related nutritional indicators before and after neoadjuvant chemotherapy were determined.ResultsAfter neoadjuvant chemotherapy,the body weight,intracellular fluid,body mass index,protein,body fat,body cell mass,and arm circumference mildly decreased;extracellular fluid,body water content,inorganic salts,bone mineral content,non-fat group,skeletal muscle,and arm muscle circumference mildly increased,but the differences were not statistically significant (P>0.05).The blood albumin,prealbumin,total protein,transferrin,and lymphocytes decreased at different degrees down,but the differences were not statistically significant(P>0.05).Conclusion Patients have no obvious changes in nutritional status during chemotherapy of FLEEOX regiment.