| 110例乳腺癌脑转移临床特点及预后因素分析 |
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| 引用本文： | 叶慧林,谢尚闹,孙才兴,俞洋,李涛,杨红健,孟旭莉. 110例乳腺癌脑转移临床特点及预后因素分析[J]. 肿瘤学杂志, 2010, 16(4): 298-300 |
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| 作者姓名： | 叶慧林 谢尚闹 孙才兴 俞洋 李涛 杨红健 孟旭莉 |
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| 作者单位： | 1. 松阳县人民医院,浙江,丽水,323400;浙江省肿瘤医院,浙江,杭州,310022
2. 浙江省肿瘤医院,浙江,杭州,310022 |
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| 摘 要： | [目的]探讨乳腺癌脑转移患者的临床病理特征及影响其预后的相关因素。[方法]分析110例乳腺癌脑转移病例的年龄、TNM分期、病理类型、组织学分级、ER/PR/HER-2表达情况、绝经状况、第一转移灶位置,以及脑转移时颅内转移灶数目,并统计1年生存率。[结果]浸润性导管癌为最常见的病理类型,组织学分级均为2/3级,单发颅内转移灶的比例为29.1%。1年生存率为33.6%,其中年龄〈50岁组的1年生存率为42.6%,≥50岁组为22.4%（P=0.026）;ER阳性患者的1年生存率为47.2%,高于ER阴性患者的26.3%（P=0.039）,颅内转移灶单发患者的1年生存率达53.1%,明显高于多发转移灶患者的25.6%（P=0.006）。[结论]首次确诊乳腺癌时的年龄、ER表达状况、颅内转移灶数量是影响乳腺癌脑转移患者预后的独立因素。
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| 关 键 词： | 乳腺肿瘤 脑转移 临床特征 预后 |
Clinical Features and Prognostic Factors for 110 Cases of Breast Cancer with Brain Metastasis |
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| Affiliation: | YE Hui-lin, XIE Shang-nao, SUN Cai-xing, et al.(1.The People’s Hospital of Songyang, Lishui 323400, China; 2. Zhejiang Cancer Hospital, Hangzhou 310022, China) |
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| Abstract: | [Purpose] To investigate the clinical features and prognostic factors of breast cancer with brain metastasis. [Methods] The clinical data of 110 breast cancer patients with brain metastasis including age, TNM stage, pathological type, histological grade, ER/PR/HER-2 status, menopausal status and first metastatic site, the number of brain metastasis at diagnosis of brain metastasis were analyzed. One-year survival was analyzed. [Results] The median age at diagnosis of breast cancer was 46 years old, the most... |
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| Keywords: | breast neoplasms brain metastasis clinical features prognosis |
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