Treatment of migraine with salmon calcitonin: effects on plasma beta-endorphin, ACTH and cortisol levels |
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Authors: | M Ustdal P Dogan A Soyuer S Terzi |
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Institution: | Department of Biochemistry and Neurology, University of Erciyes, Turkey. |
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Abstract: | In this study we have examined the results of salmon calcitonin treatment on migraine pain. The mechanism by which calcitonin induces analgesia is still not understood. We observed the effect of a 5-day treatment with salmon calcitonin (IM 100 IU/day) on circulating levels of beta-endorphin, ACTH, and cortisol in 20 patients with migraine during the headache-free period. All 3 hormones were increased after the calcitonin administration and the maximum increase was obtained in beta-endorphin levels. There were significant statistical correlations between beta-endorphin, ACTH, and cortisol levels determined before and after calcitonin treatment. |
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