| 低剂量照射在肿瘤治疗中的应用研究进展 |
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| 引用本文： | 张海兵,章龙珍.低剂量照射在肿瘤治疗中的应用研究进展[J].国际放射医学核医学杂志,2008,32(4):243-246. |
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| 作者姓名： | 张海兵 章龙珍 |
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| 作者单位： | 1. 313000 湖州, 浙江省湖州市中心医院放疗科; |
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| 摘 要： | 电离辐射生物效应与辐射剂量和剂量率有关,大、中剂量照射以损伤效应为主,低剂量照射可诱导机体的兴奋效应、适应性反应、超敏感性、旁效应等。低剂量全身照射通过诱导免疫增强效应、超敏感性、激活抗氧化酶系统及肿瘤细胞凋亡等机制具有抗肿瘤作用,降低随后较大剂量辐射诱发的肿瘤发生率。目前。低剂量照射在肿瘤防治中的应用正成为研究的热点。
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| 关 键 词： | 辐射剂量 全身照射 辐射耐受性 细胞凋亡 肿瘤治疗方案 |
| 收稿时间： | 2008-03-02 |
Advance of treatment in tumor by low-dose radiation |
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| ZHANG Hai-bing,ZHANG Long-zhen.Advance of treatment in tumor by low-dose radiation[J].International Journal of Radiation Medicine and Nuclear Medicine,2008,32(4):243-246. |
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| Authors: | ZHANG Hai-bing ZHANG Long-zhen |
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| Institution: | 1. Department of Radiation Oncology, Centrol Hospital of Huzhou, Zhejang Huzhou 313000, China; |
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| Abstract: | The biological effects of ionizing irradiation is related with dose and dose-rate.Medium to large dose irradiation can induce damaging effect to biosystem,but low dose radiation may induce adaptive response,hormesis,hyper-sensitiveness and bystander effect.Especially experimental data suggest that the antitumor effects of immune enhancement,intrinsic hypersensitivity,activation antioxidase enzymatic system and induction of apoptosis is produced by low-dose total body irradiation.Furthermore it can decrease relative cancer risk in exposed populations.Therefore,the antitumor effect by low-dose irradiation is being widely investigated and intensively researched. |
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| Keywords: | Radiation dosage Whole-body irradiation Radiation tolerance Apoptosis Antineoplatic protocols |
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