海南省管理人员体检脂肪肝的患病率调查

目的调查脂肪肝的人群、时间分布等流行病学特征，为降低脂肪肝的危害提出措施和依据。方法对2006年1～12月来我院体检的干部采用彩色B超仪进行检查并进行分级，同时检测ALT，AST，γ-GT，CH，TG，HDL—Ch，LDL—Ch，Lp—a和BS等功能及血脂指标。分析不同性别和年龄人群的脂肪肝发病率。结果脂肪肝的总发病率为34．6％（1597／4612），单纯性脂肪肝、脂肪性肝炎和脂肪性肝硬化发病率分别为29．6％、4．8％和0．2％。男性的脂肪肝发病具有双高峰。除〈30岁组的脂肪肝发病率较低外，其余各年龄组均检出较高水平。女性脂肪肝发病60～岁组最高，年龄降低和升高患病率均呈下降趋势。性别间的个性脂肪肝发生率具有显著性差异（χ^2=47．7，P〈0.001）。136例脂肪肝患者的T—CH、TG、LDL—CH、Apo B100、Lp—a、ALT、AST、χ-GT和BS均显著高于192例脂肪肝阴性者。前者的HDL—CH和Apo A显著低于后者（P〈0．05）。HBV感染者的脂肪肝阳性率显著高于HBV阴性者（χ^2=5．3，P〈0．05）。结论脂肪肝的发病率高，性别间存在显著差异，脂肪肝患者HBV阳性率升高，血脂水平异常、肝功异常和血糖水平高。

Epidemiological survey of fat liver in white-collar workers of Hainan Province

Objective To survey the incidence of fatty liver in white - collar workers and provide reference for making preventing measures. Methods There 4 612 white - collar workers for health check - up were examined by using GE＇s VIVID7 digital doppler and the levels of ALT, AST, γ - GT, CH, TG, HDL - Ch, HDL - Ch, Lp - a, BS were determined by biochemical analyzer, HBV markers were detected by indirect or sandwich ELISA. Results The morbidity of fatty liver was 34.6 % （ 1 597/4 612）. The incidence rates of fatty liver simplex, steatohepatitis and steatohepatitic cirrhosis were 29.6%, 4.8% and 0.2% respectively. The incidence in the males was high except those in the age group of less than 30 years oldgroup. The highest incidence was in the age group of 60 years old The incidence of fatty liver in males was significantly higher than that of the females（χ^2 = 47.7, P 〈 0.001）. The levels of T- CH, TG, LDL- CH, Ape B100, Lp - a, ALT, AST, r - GT and BS in 136 cases with fatty liver were significantly higher than those of the 192 ones without fatty liver, but the levels of HDL- CH and Ape A in the blood were significantly lower than their counterparts＇ . The incidence of fatty liver in those positive for HBV marker was significantly higher that of the HBV negative cases （χ^2 = 5.3, P 〈 0.05）, Conclusion The incidence of fatty liver in white - collar workers is high and especially in the males. Fatty liver is associated with high HBV infection rate, high BS and abnormal liver functions, lipid and lipoprotein level in the blood.