Effect of amiridine and tacrine on reuptake of neurotransmitters in experimental amnesia |
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Authors: | Yu V Burov T D Baimanov T N Robakidze |
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Institution: | (1) Laboratory of Psychoneuropharmacology, Russian Scientific Center for the Safety of Biologically Active Substances, Staraya Kupavna, Moscow Region |
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Abstract: | It is demonstrated that a single administration of amiridine, tacrine, piracetam, and physostigmine has no effect on the reuptake
of adrenalin, noradrenalin, dopamine, and glycine, or of γ-aminobutyric, glutamic, and aspartic acids. Scopolamine (single
administration or a 20-day treatment) also has no effect on the reuptake of these neurotransmitters. Administration of amiridine
to intact rats during a 20-day period leads to a decrease in the reuptake of dopamine and γ-aminobutyric acid. A course of
amiridine therapy of rats after repeated administration of scopolamine results in a reduced reuptake of dopamine. Tacrine,
piracetam, and physosostigmine exhibit no activity under the chosen experimental conditions.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
5, pp. 512–514, May, 1995
Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences |
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Keywords: | amiridine tacrine amnesia neutrotransmitters synaptosomal uptake |
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