| Inhibition of interleukin-13 gene expression in T cells through GATA-3 pathway by arsenic trioxide |
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| 作者单位： | Department of Respiratory Diseases,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China |
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| 基金项目： | 国家自然科学基金，江苏省自然科学基金 |
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| 摘 要： | Aarsenic trioxide （AT） has a long history of use in both traditional Chinese medicine and in modem medicine in asthma therapy. Recently, Yin et al＇ found that AT even at small doses reduced the airway inflammation of sensitized guinea pigs. However the mechanism underlying this is still largely unknown. Interleukin 13 （IL-13）, as one of the important TH2 cytokines, plays an important role in asthma pathogenesis through promoting eosinophilic inflammation,
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| 关 键 词： | 哮喘 呼吸道疾病 治疗 临床 |
Inhibition of interleukin-13 gene expression in T cells through GATA-3 pathway by arsenic trioxide |
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| YAO Xin,HE Hai-yan,HE Hai-yan,YANG Yan,DAI Shan-lin,SUN Pei-li,YIN Kai-sheng,HUANG Mao. Inhibition of interleukin-13 gene expression in T cells through GATA-3 pathway by arsenic trioxide[J]. Chinese medical journal, 2008, 121(22): 2346-2349 |
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| Authors: | YAO Xin HE Hai-yan HE Hai-yan YANG Yan DAI Shan-lin SUN Pei-li YIN Kai-sheng HUANG Mao |
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| Affiliation: | YAO Xin(Department of Respiratory Diseases,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China)；HE Hai-yan(Department of Respiratory Diseases,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China)；YANG Yan(Department of Respiratory Diseases,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China)；DAI Shan-lin(Department of Respiratory Diseases,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China)；SUN Pei-li(Department of Respiratory Diseases,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China)；YIN Kai-sheng(Department of Respiratory Diseases,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China)；HUANG Mao(Department of Respiratory Diseases,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China)；HE Hai-yan(Department of Respiratory Diseases,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China)； |
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| Abstract: | interleukin-13 asthma GATA-3 arsenic trioxide |
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| Keywords: | interleukin-13 asthma GATA-3 arsenic trioxide |
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