Dendritic branching in cortical pyramidal cells in response to ovariectomy in adult female rats: Suppression by neonatal exposure to testosterone |
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| Institution: | 1. Circulatory Physiology Department, Bogomoletz Institute of Physiology NAS of Ukraine, Bogomoletz Str 4, Kiev 01024, Ukraine;2. Institute of Molecular Biology and Biochemistry, Medical University of Graz, Harrachgasse 21/III, Graz, 8010, Austria;3. First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy;4. Ospedale Policlinico San Martino, largo Benzi 10, 16132 Genoa, Italy;5. Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 9 viale Benedetto XV, 16132 Genoa, Italy;6. Division of Cardiology, Foundation for Medical Researches, Department of Internal Medicine, University of Geneva, Av. de la Roseraie 64, CH 1211, Geneva 4, Switzerland;1. Department of Pharmacology, University of the Basque Country, UPV/EHU, Leioa, Bizkaia, Spain;2. Basque Institute of Legal Medicine, Bilbao, Spain;3. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain;4. Biocruces Health Research Institute, Barakaldo, Bizkaia, Spain;1. Department of Neurology and Allegheny Health Network Research Institute, Allegheny General Hospital, Pittsburgh, PA, USA;2. Department of Neurology, Drexel University College of Medicine, Philadelphia, PA, USA;3. Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA;4. Carnegie Mellon University, Biomedical Engineering, Pittsburgh, PA, USA |
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| Abstract: | Female Long-Evans rats were treated with oil or testosterone propionate (TP) at birth (postnatal day zero, PN0) and PN1. As adults, animals from each group were ovariectomized or sham operated. Four months later the brains were prepared using a modified Golgi-Cox staining procedure. In neonatally oil-treated females, ovariectomized in adulthood increased the dendritic arbor of layer II/III pyramidal neurons of the parietal cortex; in addition, there were modest increases in apical dendritic spine density. The dendritic arbor of the pyramidal neurons of intact neonatally TP-treated females was greater than that of intact oil-treated females, but in these animals there was no increase in dendritic arbor in response to ovariectomy. |
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