Changes in extracellular calcium concentration in the immature rat cerebral cortex during anoxia are not influenced by MK-801 |
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| Institution: | 1. Neurotherapeutics Lab, Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India;2. Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi 221005, India;3. Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India;1. Alfred-Wegener-Institute, Helmholtz Centre for Polar and Marine Research, Bremerhaven, Germany;2. Department of Geosciences, University of Bremen, Germany;3. School of Natural and Built Environment, Queen''s University Belfast, UK |
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| Abstract: | The extracellular calcium concentration (Ca2+]ec) was recorded by calcium-sensitive microelectrodes in the parietal cortex of 9–11 day old rats during anoxia. During the first 10 min of anoxia, Ca2+]ec increased from 1.1 mM to 1.5 ± 0.23 mM, and thereafter it started to decrease reaching below basal level after around 13 min. The Ca2+]ec decrease was either slow and continuous, or biphased with a rapid initial decrease followed by a continuous slow decrease. After 60 min of anoxia, the Ca2+]ec had reached 0.2–0.3 mM. Changes in Ca2+]ec in animals treated with the NMDA receptor antagonist MK-801 (0.3 mg/kg i.p.) did not display any significant differences compared to controls. Thus, the strong neuroprotective effect of MK-801 in ischemic situations in the immature brain can not be explained by a prevention of calcium entry during anoxic depolarization. |
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