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Development of vaccines against malaria
Affiliation:1. Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA;2. School of Life Sciences, Jilin University, Changchun, 130012, China;3. College of Pharmacy, The Ohio State University, Columbus, OH 43212, USA;4. Division of Hematology, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43212, USA;5. Tumor Biomarker Research Center, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China;6. Peking Union Medical College, Beijing 100021, China;1. Department of Internal Medicine, Lyon University Hospital, Lyon, France;2. Department of Gastroenterology, Besancon University Hospital, Besancon, France;3. Department of Anesthesiology and Critical Care, Lariboisière University Hospital, AP-HP, ECSTRA Team, CRESS, Epidemiology and Statistics Center, Sorbonne Paris Cité, UMR 1153, INSERM, University Denis Diderot - Paris VII, Paris, France
Abstract:Substantial progress towards development of a vaccine against Plasmodium falciparum malaria has been accomplished. A number of vaccine candidate antigens have been identified and in some of these antigens immunodominant B-cell and T-cell epitopes have been defined. New adjuvants and delivery systems suitable for human vaccines are available. The selection of suitable epitopes and their assembly in multi-antigenic constructs are research tasks for the future.
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