Superantigens and retroviral infection: insights from mouse mammary tumor virus |
| |
| Affiliation: | 1. Division of Allergy Immunology, The Children''s Hospital of Philadelphia, Philadelphia, PA 19104, United States;2. The Center for Biomedical Informatics, The Children''s Hospital of Philadelphia, Philadelphia, PA 19104, United States;3. Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States |
| |
| Abstract: | Superantigens induce a vigorous immune response by stimulating T cells that express particular T-cell receptor Vβ chains. Mouse mammary tumor virus is a milk-transmitted retrovirus that encodes such a superantigen. Paradoxically, as discussed by Werner Held and colleagues, the strong superantigen-induced immune response permits the survival of the virus via T-cell dependent clonal expansion of infected B cells. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
