Estrogen and progesterone receptor status of central giant cell lesions of the jaws |
| |
| Affiliation: | 1. Department of Oral Diagnosis and Patient Services Augusta, Ga., USA;2. Department of Oral Pathology, School of Dentistry, Medical College of Georgia Augusta, Ga., USA;3. Department of Oral Pathology, School of Dentistry Morgantown, W. Va., USA;4. Department of Pathology, School of Medicine, West Virginia University Morgantown, W. Va., USA;1. Department of Physics, Andhra University, Visakhapatnam-530003, India;2. Advanced Analytical Laboratory, Andhra University, Visakhapatnam-530003, India;1. Research Prof., Dr., Department of Earth & Environmental Sciences, Institute of Environmental Geosciences, Pukyong National University, 599-1 Daeyeon-dong Nam-gu, Busan 608-737, Korea;2. Dr., Department of Earth Sciences, Annamalai University, Annamalai Nagar 608-502, Tamil Nadu, India;3. Prof., Department of Earth & Environmental Sciences, Institute of Environmental Geosciences, Pukyong National University, 599-1 Daeyeon-dong Nam-gu, Busan 608-737, Korea;4. Prof., Department of Earth Sciences, Annamalai University, Annamalai Nagar 608-502, Tamil Nadu, India;5. Research Scholar., Department of Earth Sciences, Annamalai University, Annamalai Nagar 608-502, Tamil Nadu, India;6. Dr., K-Water Institute, Korea Water Resources Corporation, Daejeon 305-730, Korea;1. Orthopaedics and Traumatology Department, University Hospital of Nantes CHU, Hôtel-Dieu, 44 093 Nantes Cedex, France;2. LPRO, Inserm U957, UFR Médecine, Université de Nantes, 1 Rue Gaston Veil, 44000 Nantes, France;3. Univeristy Hospital de la Conception, 147 Bd Baille, 13005 Marseille, France;4. University Hospital de Hautepierre, Av. Molière, 67 000 Strasbourg, France;5. University Hospital Trousseau, Rue des Loches, 37 004 Tours, France;6. University Hospital of Purpan, Place du Dr. Baylac, 31 059 Toulouse, France;7. University Hospital Dupuytren, Av. Martin Luther King, 87 042 Limoges, France;8. University Hospital of Cochin-Port Royal, Av. Du Fb Saint Jacques, 75 014 Paris, France;1. Researcher, Department of Biomedical and Neuromotor Sciences, Section of Maxillofacial Surgery, Policlinico Sant''Orsola-Malpighi, University of Bologna, Bologna, Italy;2. PhD student, Department of Biomedical and Neuromotor Sciences, Section of Oral Science, University of Bologna, Bologna, Italy;3. Medical Doctor, Department of Biomedical and Neuromotor Sciences, Section of Maxillofacial Surgery, Policlinico Sant''Orsola-Malpighi, University of Bologna, Bologna, Italy;4. Professor of Oral and Maxillofacial Surgery, Department of Biomedical and Neuromotor Sciences, Section of Maxillofacial Surgery, Policlinico Sant''Orsola-Malpighi, University of Bologna, Bologna, Italy |
| |
| Abstract: | It is well known that the central giant cell lesion (granuloma) of the jaws has a distinct female predilection. In addition, occasional cases of central giant cell lesion have been reported to have undergone marked proliferation in pregnant patients and in those undergoing hormonal therapy. As such, we have evaluated 10 central giant cell lesions for the detection of estrogen and progesterone receptor proteins with the use of immunoperoxidase staining. Surprisingly, however, immunostaining for estrogen receptor protein was essentially negative in all cases examined. Although an occasional mononuclear cell stained weakly positive for estrogen receptor protein, these findings suggest that in most cases, factors other than a direct influence of the ovarian hormones, estrogen and progesterone, are responsible for the development and growth of these lesions. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
