肺鳞癌中MMP-2,MMP-9,TIMP-1的表达及与预后的关系

目的 :研究肺鳞癌中基质金属蛋白酶 (MMP 2 ,MMP 9) ,金属蛋白酶组织抑制剂 (TIMP 1)的表达及其与临床病理特征、淋巴结转移和预后的关系。方法 :免疫组织化学S P法进行检测。结果 :MMP 2 ,MMP 9,TIMP 1在肺鳞癌中的表达率分别为 72 .5 %、5 5 %和 72 .5 %。表达强度与淋巴结转移显著相关 (P <0 .0 1,P<0 .0 1,P <0 .0 5 ) ,与术后平均生存期显著相关 (P<0 .0 5 )。与年龄、性别、组织学类型、分化程度无关。结论 :淋巴结转移是影响肺癌病人预后的指标。

Expressions of MMP-2, MMP-9,TIMP-1 and Their Relationships With Prognosis of Squamous Cell Carcinoma of Lung

Objective: Our aim was to study the expression of matrix metalloproteinase (MMP-2, MMP-9),and tissue inhibitor of metalloproteinase (TIMP-1) in squamous cell carcinoma of lung and their relationships with the clinicopathological feature, metastasis, and prognosis. Methods:We used the S-P method of immunohistochemical technique. Results:Positive expression rates of MMP-2, MMP-9,TIMP-1 were 72.5%, 55.0%,72.5% respectively. There were statistical relationship between immuno-reactivity of MMP-2, MMP-9,TIMP-1 and lymphatic metastasis(P<0.01,P< 0.01,P<0.05). There were significant differences between immuno-reactivity of MMP-2, MMP-9,TIMP-1 and prognosis. Conclusion:There were no significant differences between the expressions of MMP-2,MMP-9,TIMP-1 and age, sex, histological type and differentiation of patients, but the expression were closely related to lymphatic metastasis and prognosis.