赤芍加清胰汤联合空肠营养治疗重症急性胰腺炎的临床效果

目的 观察赤芍加清胰汤联合空肠营养治疗重症急性胰腺炎的临床效果。方法 选取2014年12月~2019年1月在我院治疗的90例重症急性胰腺炎患者，随机分为对照组和观察组，各45例。对照组给予常规西医治疗，观察组在对照组基础上加用赤芍加清胰汤联合空肠营养治疗，比较两组临床治疗总有效率、腹痛和腹胀症状消失时间、血尿淀粉酶恢复时间、炎性指标（TNF-α、IL-6、IL-18）以及住院期间感染率和不良反应发生率。结果 观察组治疗总有效率为95.56%，高于对照组的80.00%，差异有统计学意义（P＜0.05）；观察组腹痛和腹胀症状消失时间（5.33±2.73）d、血尿淀粉酶恢复时间为（4.48±2.70）d，均短于对照组的（7.31±3.20）d、（6.61±3.09）d，差异有统计学意义（P＜0.05）；观察组TNF-α、IL-6、IL-18水平均低于对照组，差异有统计学意义（P＜0.05）；观察组住院期间感染率为8.89%、不良反应发生率为4.44%，分别低于对照组的15.56%、11.11%，差异有统计学意义（P＜0.05）。结论 赤芍加清胰汤联合空肠营养治疗重症急性胰腺炎疗效确切，患者临床症状消退快，可促进炎性因子的吸收，降低血清炎性指标含量，且临床用药安全性良好，具有较好的临床应用效果。

Clinical Observation on Treatment of Severe Acute Pancreatitis with Chishao Plus Qingyi Decoction Combined with Jejunal Nutrition

Objective To observe the clinical effect of Chishao plus Qingyi decoction combined with jejunal nutrition in the treatment of severe acute pancreatitis. Methods 90 patients with severe acute pancreatitis who were treated in our hospital from December 2014 to January 2019 were randomly divided into the control group and the observation group, with 45 cases in each group. The control group was treated with conventional western medicine. The observation group was treated with Chishao plus Qingyi decoction combined with jejunal nutrition on the basis of the control group. The total effective rate of clinical treatment, the disappearance time of abdominal pain and bloating symptoms, the recovery time of hematuria and amylase, and the time of hematuria were observed. Inflammatory markers (TNF-α, IL-6, IL-18) and the incidence of infection and adverse reactions during hospitalization. Results The total effective rate of the observation group was 95.56%, which was higher than that of the control group 80.00%,the difference was statistically significant (P<0.05). The disappearance time of abdominal pain and bloating symptoms in the observation group was (5.33±2.73) d, and the recovery time of hematuria was (4.48±2.70)d, both were shorter than the control group (7.31±3.20)d, (6.61±3.09)d, the difference was statistically significant (P<0.05);The levels of TNF-α, IL-6 and IL-18 in the observation group were lower than those in the control group,the difference was statistically significant (P<0.05). The infection rate was 8.89% and the incidence of adverse reactions was 4.44% in the observation group, which was lower than 15.56% and 11.11% of the control group, respectively,the difference was statistically significant (P<0.05).Conclusion Chishen plus Qingyi decoction combined with jejunal nutrition is effective in the treatment of severe acute pancreatitis. The clinical symptoms of patients with rapid disappearance can promote the absorption of inflammatory factors, reduce the serum inflammatory index, and have good clinical safety clinical application effects.