妇女宫颈病变筛查分析

目的 研究HPV与宫颈癌及癌前病变的相关性，提供防治宫颈癌的思路。方法 以2012年1月~2017 年12月送检到浙江迪安诊断技术股份有限公司的433447例宫颈病变标本为研究对象，同时检测人乳头瘤病毒（HPV）基因分型和薄层液基细胞学（TCT），并分析HPV基因亚型分布及年龄分布。结果 HPV阳性率为12.51%，其中单一高危HPV阳性率为9.28%，单一低危HPV阳性率为1.22%。HPV亚型阳性率最高的是16型2.09%、58型1.82%、52型1.61%。TCT 阳性检出率是5.69%，其中 ASC-US3.91%、LSIL1.21%、ASC-H0.32%、HSIL及以上0.23%、AGC 0.02%。HPV发病率最高的年龄段是41~50岁，阳性率为5.54%，与其它年龄段比较，差异有统计学意义（P＜0.05）。结论 HPV亚型中16、52及58感染率最高，同时具有明显年龄特征。HPV感染可引起一系列的宫颈病变，防治重点应针对高危HPV感染的人群。

Screening Analysis of Cervical Lesions in Women

Objective To study the correlation between HPV and cervical cancer and precancerous lesions, and to provide ideas for the prevention and treatment of cervical cancer. Methods From January 2012 to December 2017, 433,447 cases of cervical lesions were sent to Zhejiang Dian Diagnostics Technology Co., Ltd. for the detection of human papillomavirus (HPV) genotyping and thin-layer liquid-based cells. (TCT), and analysis of HPV gene subtype distribution and age distribution.Results The positive rate of HPV was 12.51%, of which the single high-risk HPV positive rate was 9.28%, and the single low-risk HPV positive rate was 1.22%. The highest positive rates of HPV subtypes were type 16 (2.09%), type 58 (1.82%), and type 52 (1.61%). The positive rate of TCT was 5.69%, including ASC-US (3.91%), LSIL (1.21%), ASC-H (0.32%), HSIL and above (0.23%), and glandular epithelial lesions (0.02%). The age group with the highest incidence of HPV was 41-50 years old, and the positive rate was 5.54%. Compared with other age groups, the difference was statistically significant (P<0.05).Conclusion The HPV subtypes have the highest infection rates of 16, 52 and 58 and have obvious age characteristics. HPV infection can cause a series of cervical lesions, and the focus should be on people with high-risk HPV infection.