纳洛酮联合亚低温疗法基础治疗脑出血的临床效果观察

目的 观察纳洛酮联合亚低温疗法对脑出血进行基础治疗的临床效果，以及血清氧化应激产物在治疗前后的变化。方法 选取2015年12月~2016年10月我院收治的脑出血患者80例，随机分为亚低温疗法组和联合组，每组40例。亚低温疗法组采用亚低温疗法治疗，联合组采用纳洛酮联合亚低温疗法治疗。比较两组的临床治疗效果、治疗前后血清氧化应激产物水平和美国国立卫生研究院卒中量表（NIHSS）评分的变化。结果 联合组的临床总有效率为90.00%，高于亚低温治疗组的77.50%，差异有统计学意义（P＜0.05）。治疗后，两组患者血清SOD、MDA水平均较治疗前降低，且联合组的SOD和MDA水平均低于亚低温治疗组，差异有统计学意义（P＜0.05）。经治疗后，两组患者NIHSS评分均降低，且联合组低于亚低温治疗组，差异有统计学意义（P＜0.05）。结论 纳洛酮联合亚低温疗法治疗急性脑出血，临床疗效显著，可有效降低患者血清氧化应激产物水平，改善患者神经功能状态。

Clinical Observation of Naloxone Combined with Mild Hypothermia Therapy for Cerebral Hemorrhage

Objective To observe the clinical effect of naloxone combined with mild hypothermia on basic treatment of cerebral hemorrhage and the changes of serum oxidative stress products before and after treatment. Methods 80 patients with cerebral hemorrhage admitted to our hospital from December 2015 to October 2016 were randomly divided into the hypothermia therapy group and the combination group, with 40 patients in each group. The hypothermia group was treated with mild hypothermia and the combination group was treated with naloxone in combination with hypothermia. The clinical effects of the two groups, serum oxidative stress levels before and after treatment, and changes in the National Institutes of Health Stroke Scale (NIHSS) scores were compared. Results The total clinical effective rate was 90.00% in the combined group, which was higher than 77.50% in the hypothermia treatment group,the difference was statistically significant (P<0.05). After treatment, the levels of serum SOD and MDA in the two groups were lower than those before treatment, and the SOD and MDA levels in the combined group were lower than those in the hypothermia group (P<0.05). After treatment, the NIHSS scores of the two groups were lower, and the combined group was lower than the hypothermia treatment group, the difference was statistically significant (P<0.05).Conclusion Naloxone combined with mild hypothermia therapy for acute cerebral hemorrhage has a significant clinical effect, which can effectively reduce the level of serum oxidative stress and improve the neurological status of patients.