消化性溃疡患者Cag A蛋白及Gas的水平变化特点及诊断学价值分析

目的:探究消化性溃疡患者Cag A蛋白及Gas的水平变化特点，评价两种因子对于消化性溃疡的诊断学价值。方法:选取2016年1月-2017年6月我院消化科收治的128例良性消化道疾病患者为观察组，检测各受试者血清Cag A蛋白表达阳性率及血清Gas水平均值，并以大于所有受试者血清Gas浓度中位数为阳性限，后经胃镜确诊128例患者中胃溃疡35例，十二指肠溃疡45例，慢性胃炎48例，统计各类病变患者Cag A蛋白表达阳性率及血清Gas阳性率，分析Cag A蛋白阳性表达和血清Gas阳性表达两个指标对消化性溃疡诊断的敏感性及特异性。结果:在128例消化性溃疡患者中，94例血清Cag A检测呈阳性，敏感性为73.43%（94/128），在健康体检者中，104例血清Cag A检测呈阴性，特异性为81.28%（104/128），消化性溃疡患者血清Gas浓度均值为（56.89±9.24）ng/L，显著高于对照组（40.68±8.27）ng/L。选取所有受试者血清Gas浓度中位数46.50 ng/L 为阳性，对消化性溃疡诊断的敏感性为79.68%（102/128），特异性为83.59%。结论:消化性溃疡患者血清Cag A阳性表达率和Gas水平均显著高于健康人群，两项指标在消化性溃疡诊断中均具有较高的敏感性和特异性。

Changes of Cag A protein and Gas levels in patients with peptic ulcer and their diagnostic value

Objective: To explore the specificity and sensitivity of Cag A protein expression and Gas level change in the diagnosis of peptic ulcer, and to explore the significance of serum Cag A protein and Gas detection in the diagnosis of peptic ulcer. Methods:From Jan 2016 to Jun 2017, 128 cases of active peptic ulcer patients were admitted to our hospital. gastroenterology observation group included 128 cases, and 120 cases over the same period were chosen as the healthy control group. Serum Cag of subjects were compared. The positive rate of protein A expression and the mean of serum Gas water were higher than the median concentration of serum Gas in all subjects. The sensitivity of two markers, Cag A protein expression and serum Gas-positive expression, was used to diagnose peptic ulcer and specificity. Results:In 128 cases of peptic ulcer patients, 94 cases of serum Cag A were detected positive withsensitivity of 73.43% (94/128) in healthy subjects, while 104 cases were with negative serum Cag A, and a specificity of 81.28% (104/128). Table 2 The results showed that the mean serum concentration of Gas in patients with peptic ulcer was (56.89±9.24) ng/L, which was significantly higher than that of the control group (40.68±8.27) ng/L. The median serum concentration of Gas was 46.50 ng/L in all subjects. The sensitivity for the diagnosis of peptic ulcer was 79.68%(102/128) and the specificity was 83.59%. Conclusion:The positive rate of peptic ulcer patients and Gas Cag A serum levels were significantly higher than healthy people, and the two indicators in the diagnosis of peptic ulcer have high sensitivity and specificity.