| EFNA3在结直肠癌中的表达及临床意义 |
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| 引用本文： | 段洁, 何艺伟, 谢明, 杨沙, 陈贤永, 周君, 曹慧秋. EFNA3在结直肠癌中的表达及临床意义[J]. 分子影像学杂志, 2019, 42(4): 548-550. doi: 10.12122/j.issn.1674-4500.2019.04.29 |
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| 作者姓名： | 段洁 何艺伟 谢明 杨沙 陈贤永 周君 曹慧秋 |
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| 作者单位： | 1.湘南学院 2015级临床医学系;;2.湘南学院 基础医学院;;3.湘南学院 病理研究所;;4.湘南学院 附属医院病理科，湖南 郴州 423000;;5.郴州市第一人民医院中心医院病理科，湖南 郴州 423000 |
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| 基金项目： | 湖南省自然科学基金（2016JJ6143）；湘南学院一般项目（2015XB19）；湖南省卫生计生委一般项目（C2016048）；郴州市科技局项目（1） |
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| 摘 要： | 目的研究EFNA3在结直肠癌中的表达及关系。方法随机选取湘南学院附属医院84例结直肠病例，分结直肠癌、结直肠良性肿瘤和正常结直肠组织3组，采用免疫组织化学方法分别检测3组中EFNA3的表达情况。结果EFNA3在结直肠癌组中的表达强度为3.6±1.3，相比良性结直肠肿瘤组（5.1±0.6）和正常结直肠组（4.9±1.3）较低（P<0.05）。高分化组EFNA3表达量高于低分化组（4.2±0.4 vs 3.3±1.6，P<0.05)；有淋巴结转移组肿瘤组织中EFNA3的表达量低于无淋巴结转移组（3.3±1.7 vs 4.13±0.28，P<0.05)；TNM分期Ⅲ+Ⅳ者肿瘤组织中 EFNA3表达量低于Ⅰ+Ⅱ者（3.3±1.7 vs 4.13±0.28，P<0.05)。结论EFNA3随着癌症发生过程的逐渐深入而表达递减，表明可能与结直肠癌的发生过程有关并在其中起到了类似抑癌基因的作用。
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| 关 键 词： | EFNA3 结直肠癌 免疫组织化学 |
| 收稿时间： | 2019-07-30 |
Expression of EFNA3 in colon cancer and its clinical significance |
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| Jie DUAN, Yiwei HE, Ming XIE, Sha YANG, Xianyong CHEN, Jun ZHOU, Huiqiu CAO. Expression of EFNA3 in colon cancer and its clinical significance[J]. Journal of Molecular Imaging, 2019, 42(4): 548-550. doi: 10.12122/j.issn.1674-4500.2019.04.29 |
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| Authors: | Jie DUAN Yiwei HE Ming XIE Sha YANG Xianyong CHEN Jun ZHOU Huiqiu CAO |
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| Affiliation: | 1. Department of Clinical Medicine, Grade 2015;;2. Basic Medical College;;3. Institute of Pathology;;4. Department of Pathology, Affiliated Hospital of Xiangnan University, Chenzhou 423000, China;;5. Department of Pathology, Central Hospital of Chenzhou First People's Hospital, Chenzhou 423000, China |
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| Abstract: | ObjectiveTo investigate the expression of EFNA3 in colorectal cancer preliminary to explore the relationship between EFNA3 and colorectal cancer.MethodsA total of 84 colorectal cancer cases in XiangNan University affiliated hospital were randomly selected. They were divided into 3 groups: colorectal cancer, colorectal benign tumor and normal colorectal tissue. Immunohistochemistry was used to detect the expression of EFNA3 in 3 groups.ResultsExpression intensity of EFNA3 in colorectal cancer (3.6±1.3) was lower than that in colorectum benign tumor (5.1±0.6, P<0.05) and Normal colorectum (4.9±1.3, P<0.05). Compared with the expression of EFNA3 in the tumor tissues of well-differentiated group (4.2±0.4) and poorly differentiated group (3.3±1.6), the former was lower than the latter (P<0.05). The expression of EFNA3 in the tumor tissues in the lymphatic metastasis group (3.3±1.7) was lower than not (4.13±0.28) (P<0.05). Compared with the expression of EFNA3 in the tumor tissues people at Ⅲ+Ⅳ (3.3±1.7) and Ⅰ+Ⅱ (4.13±0.28) TNM staging, the former was lower than the latter (P<0.05).ConclusionThe expression of EFNA3 is lower in Colorectal cancer. Colorectum benign tumor and Normal colorectum have no significant difference. |
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| Keywords: | EFNA3 colorectum cancer immunohistochemistry |
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