蛛网膜下腔出血与胃泌素-17的相关性研究

目的:探讨胃泌素-17（GAS-17）在蛛网膜下腔出血患者血清的表达及意义。方法:采用酶联免疫法测定了255例蛛网膜下腔出血患者、255例体检者血清的GAS-17变化。蛛网膜下腔出血同时测定幽门螺旋杆菌lgG（HP-lgG）抗体。结果:蛛网膜下腔出血组GAS-17较对照组明显增高（5.75 pmol/L vs. 2.72 pmol/L，Z =-7.110，P =0.000）。蛛网膜下腔出血组的HP-lgG抗体阳性与HP-lgG抗体阴性GAS-17含量比较差异无统计学意义（Z =-0.384，P =0.701）。结论:GAS-17升高可能参与蛛网膜下腔出血患者应激性溃疡的发生发展。

Correlation between serum gastrin-17 and subarachnoid hemorrhage

Objective: To investigate the expression and significance of the gastrin-17(GAS-17) content in subarachnoid hemorrhage patients. Methods: ELISA was used to measure the serum concentration of GAS-17 in 255 patients with subarachnoid hemorrhage and 255 healthy people. HP-lgG antibodies were detected in patients with subarachnoid hemorrhage. Results: For patients with subarachnoid hemorrhage, the serum GAS-17 were compared with those in the normal group, and the difference was statistically significant (5.75 pmol/L vs. 2.72 pmol/L, Z =-7.110，P =0.000). The value of GAS-17 increased significantly in patients with subarachnoid hemorrhage. In the group with subarachnoid hemorrhage, there was no significant difference between the GAS-17 content and whether the antibody of HP-lgG was positive or not(Z =-0.384，P =0.701). Conclusion: Elevated serum GAS-17 might be involved in the pathogenesis of stress ulcer of subarachnoid hemorrhage.