丙酸氟替卡松联合特布他林治疗COPD急性加重期的效果

目的 分析慢阻肺急性加重期患者应用丙酸氟替卡松联合特布他林治疗的临床效果。方法 将本院2017年7月~2018年6月收治的90例慢阻肺急性加重期患者作为研究对象，随机分为对照组与研究组，各45例。对照组应用特布他林治疗，研究组在此基础上加用丙酸氟替卡松进行治疗。比较两组临床疗效，血气指标和肺通气功能改善情况。结果 研究组治疗总有效率为86.67%，高于对照组的51.11%，差异有统计学意义（P＜0.05）；治疗后研究组PaO2（87.68±5.36）mmHg和PaCO2（32.64±6.51）mmHg优于对照组的（80.67±5.61）mmHg、（38.74±6.42）mmHg，差异有统计学意义（P＜0.05）；治疗后研究组FEV1（2.38±0.59）L、FVC（3.79±0.60）L、FEV1/FVC（68.54±5.06）%优于对照组的（2.04±0.58）L、（3.16±0.62）L、（58.84±4.96）%，差异有统计学意义（P＜0.05）。结论 丙酸氟替卡松联合特布他林治疗慢阻肺急性加重期患者疗效确切，可以有效改善患者血气指标和肺通气功能，值得临床借鉴。

Effect of Fluticasone Propionate Combined with Terbutaline on Acute Exacerbation of COPD

Objective To analyze the clinical effect of fluticasone propionate combined with terbutaline in patients with acute exacerbation of chronic obstructive pulmonary disease. Methods 90 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to our hospital from July 2017 to June 2018 were randomly divided into control group and study group, with 45 cases in each group. The control group was treated with terbutaline, and the study group was treated with fluticasone propionate. The clinical efficacy, blood gas index and improvement of pulmonary ventilation function were compared between the two groups. Results The total effective rate of the study group was 86.67%, which was higher than that of the control group 51.11%,the difference was statistically significant (P<0.05). After treatment, the study group PaO2 (87.68±5.36) mmHg and PaCO2 (32.64±6.51) mmHg were better than the study group. The control group had (80.67±5.61) mmHg and (38.74±6.42) mmHg, the difference was statistically significant (P<0.05). After treatment, the study group FEV1 (2.38±0.59)L, FVC (3.79±0.60)L,FEV1/FVC (68.54±5.06)% was superior to the control group (2.04±0.58)L, (3.16±0.62)L, (58.84±4.96)%,the difference was statistically significant (P<0.05).Conclusion Fluticasone propionate combined with terbutaline is effective in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease. It can effectively improve the blood gas index and lung ventilation function of patients, which is worthy of clinical reference.