中年无症状性脑梗死事件相关电位P300变化及其与 认知功能的相关性研究

目的 探讨中年无症状性脑梗死事件相关电位P300变化及与认知功能的相关性。方法 选择2017年5月~2018年10月我院收治的中年无症状性脑梗死患者71例设为观察组，选择同期治疗的非脑梗死患者65例设为对照组。两组入院后均采用NEUROPACK型肌电图及诱发电位仪完成事件相关电位P300测定，采用HAMD、MMSE检查量表评估认知功能，并分析中年无症状性脑梗死事件电位P300与认知功能相关性。结果 观察组P3L、HAMD评分高于对照组（384.57±24.71）vs（350.51±24.59）、（23.23±2.31）分vs（14.51±1.95）分]，Amp、MMSE评分低于对照组（11.67±2.15）vs（16.89±3.49）、（20.12±0.34）分vs（24.69±0.62）分]，差异有统计学意义（P＜0.05）。中年无症状性脑梗死事件电位P300与认知功能相关性分析结果表明:P3L与HAMD评分呈正相关性（r=0.693，P=0.017），MMSE评分呈负相关性（r=-0.392，P=0.033）；事件电位Amp与HAMD评分呈负相关性（r=-0.592，P=0.039），MMSE评分呈正相关性（r=0.593，P=0.044）。结论 中年无症状性脑梗死患者常伴有相关电位P300变化，表现为潜伏期延长及波幅下降，与认知功能存在相关性，能评估患者疾病严重程度。

Changes of Event-related Potential P300 in Middle-aged Patients with Asymptomatic Cerebral Infarction and Its Correlation with Cognitive Function

Abstract:Objective To investigate the changes of event-related potential P300 in middle-aged asymptomatic cerebral infarction and its correlation with cognitive function.Methods 71 middle-aged patients with asymptomatic cerebral infarction treated from May 2017 to October 2018 were selected as observation group, and 65 non-cerebral infarction patients treated at the same time were selected as control group. Event-related potential P300 was measured by NEUROPACK electromyography and evoked potential instrument in both groups after admission. Cognitive function of the two groups was evaluated by HAMD and MMSE scales.Results The P3L and HAMD in the observation group were higher than that in the control group (384.57±24.71) vs (350.51±24.59),(23.23±2.31) scores vs(14.51±1.95) scores], the Amp and MMSE were lower than that in the control group (11.67±2.15) vs (16.89±3.49),(20.12±0.34) scores vs (24.69±0.62) scores],the difference was statistically significant(P<0.05). The correlation analysis between event-related potential P300 and cognitive function in middle-aged patients with asymptomatic cerebral infarction showed that the P3L was positively correlated with the HAMD score (r=0.693,P=0.017), the MMSE score was negatively correlated (r=-0.392,P=0.033); the Amp was negatively correlated with the HAMD score (r=-0.592,P=0.039), the MMSE score was positively correlated(r=0.593,P=0.044).Conclusion Middle-aged patients with asymptomatic cerebral infarction are often accompanied by changes of correlation potential P300, which is characterized by prolonged latency and decreased amplitude. It is correlated with cognitive function and can evaluate the severity of the disease.