一步法制备携载治疗剂的树枝状大孔二氧化硅纳米粒子

目的:通过双模板策略一步法制备携载治疗剂的树枝状大孔二氧化硅纳米粒子（DLMSNs）。方法:以十六烷基三甲基溴化铵（CTAB）为模板剂，以治疗剂二茂铁甲酸（FCA）或血卟啉二盐酸盐（HP）为辅助模板剂，制备了DLMSNs。通过透射电子显微镜（TEM）、激光粒度仪和红外光谱（FT-IR）表征了DLMSNs的形貌、粒径、红外吸收特征等。结果:所得DLMSNs具有中心径向结构，粒径小于100 nm，单分散性好。通过调整CTAB与辅助模板的比例，可以很好地控制DLMSNs的孔径和粒径。通过选择合适的方法除掉CTAB后，辅助模板剂仍有一定量保留在DLMSNs中，并进一步发挥抗肿瘤的治疗作用。结论:该方法不仅避免了以前报道的有毒辅助模板剂的使用，而且仅以水为反应溶剂，避免了使用有毒的有机溶剂。将为DLMSNs的制备提供一种简单可行的方法。

One-step synthesis of therapeutic agent loaded dendritic large-pore mesoporous silica nanoparticles

Objective: To prepare one-step synthesis of therapeutic agent loaded dendritic large-pore mesoporous silica nanoparticles (DLMSNs) via dual-templating strategy. Methods: DLMSNs were prepared by using cetyltrimethylammonium bromide (CTAB) as templates and therapeutic agents as auxiliary templates in this study. The morphology, particle size and infrared absorption of DLMSNs were characterized by transmission electron microscopy (TEM), laser particle size analyzer and Fourier transform infrared spectra (FT-IR). Results: The obtained DLMSNs showed a central-radial structure with the size below 100 nm and excellent monodispersity. The pore size and partical size of DLMSNs were well controlled by adjusting the ratio of CTAB to auxiliary templates. Importantly, the auxiliary templates remained in DLMSNs after removing CTAB by choosing the appropriate treatment, indicating a therapeutic effect in tumor therapy. Conclusion: This method not only avoids using the toxic auxiliary templates reported previously, but also averts the toxic organic solvent by only using aqueous solution as reaction condition. The study will provide a simple and feasible way to prepare the DLMSNs for biomedical application.