微粒化黄体酮治疗闭经及无排卵性异常子宫出血的疗效

目的 分析口服微粒化黄体酮胶囊治疗闭经及无排卵性异常子宫出血的临床疗效。方法 选取2015年6月~2018年6月在我院诊治的116例闭经及无排卵性功能失调性子宫出血患者为研究对象，采用随机数字表法分为对照组和观察组，各58例。对照组采用醋酸甲羟孕酮片治疗，观察组口服微粒化黄体酮胶囊治疗，比较两组治疗前后月经周期指标（月经周期、子宫内膜厚度、月经期）、内分泌功能指标血清卵泡雌激素（FSH）、黄体生成素（LH）及雌二醇（E2）水平及不良反应。结果 治疗后两组月经周期、子宫内膜厚度、月经期均低于治疗前，且观察组低于对照组（P＜0.05）；治疗后两组FSH、LH、E2均低于治疗前，且观察组低于对照组（P＜0.05）；观察组不良反应发生率（10.34%）与对照组（12.06%）比较，差异无统计学意义（P＞0.05）。结论 口服微粒化黄体酮胶囊在调控闭经及无排卵性功能失调性子宫出血中具有确切的疗效，可缩短月经周期、月经期，减小子宫内膜厚度，且不良反应少，具有临床应用价值。

Effect of Micronized Progesterone in Treating Amenorrhea and Anovulatory Abnormal Uterine Bleeding

Objective To analyze the clinical efficacy of oral micronized progesterone capsules for amenorrhea and anovulatory abnormal uterine bleeding. Methods A total of 116 patients with amenorrhea and anovulatory dysfunctional uterine bleeding diagnosed and treated in our hospital from June 2015 to June 2018 were selected as the research subjects. They were divided into the control group and the observation group by random number table method, with 58 cases in each group. The control group was treated with medroxyprogesterone acetate tablets, the observation group was treated with micronized progesterone capsules orally,compare the menstrual cycle indicators(menstrual cycle, endometrial thickness, menstrual period), endocrine function indicators serum follicle estrogen (FSH), luteinizing hormone (LH), and estradiol (E2) levels and adverse reactions before and after treatment between the two groups. Results The menstrual cycle, endometrial thickness, and menstrual period of the two groups were lower than those before treatment, and the observation group was lower than that of the control group(P<0.05).After treatment, FSH, LH, and E2 in the two groups were lower than before treatment, and the observation group was lower than the control group, the difference was statistically significant(P<0.05); the incidence of adverse reactions in the observation group(10.34%) compared with the control group(12.06%), the difference was not statistically significant(P>0.05).Conclusion Oral micronized progesterone capsules are effective in regulating amenorrhea and anovulatory dysfunctional uterine bleeding. It can shorten the menstrual cycle, menstrual period, reduce the thickness of the endometrium, and has fewer adverse reactions. It has clinical application value.