盐酸米诺环素软膏与甲硝唑对种植体周围炎抑制作用的 临床研究

目的 对比局部运用盐酸米诺环素软膏和口服甲硝唑治疗种植体周围炎的临床效果。方法 选取2016年3月~2018年5月来我院口腔门诊就诊的种植体周围炎患者36例，在对种植体进行龈上洁治、龈下刮治后，随机分为盐酸米诺环素软膏组和口服甲硝唑组，每组18例。盐酸米诺环素软膏组局部运用盐酸米诺环素软膏治疗，口服甲硝唑组采用口服甲硝唑治疗。对比基线、治疗后4周和8周改良菌斑指数（mPLI）、改良龈沟出血指数（mSBI）和探诊深度（PD）参数。结果 治疗后4周及8周，两组患者mPLI、mSBI以及PD参数均低于基线，差异具有统计学意义（P＜0.05）；盐酸米诺环素软膏组治疗后4周及8周的mPLI、mSBI以及PD参数均低于口服甲硝唑组4周:mPLI（0.69±0.47）vs （1.46±0.33），mSBI（0.62±0.41） vs （1.16±0.38），PD（2.47±0.37）mm vs （3.52±0.54）mm；8周:mPLI（0.98±0.39）vs（1.52±0.30），mSBI（0.86±0.45）vs（1.26±0.43），PD（2.93±0.50）mm vs （3.46±0.46）mm]，差异具有统计学意义（P＜0.05）。结论 盐酸米诺环素软膏和甲硝唑治疗种植体周围炎有确切的疗效，应用盐酸米诺环素软膏效果明显优于口服甲硝唑，局部使用药物可以实现短期的大幅优化。

Clinical Study on the Inhibitory Effect of Minocycline Hydrochloride Ointment and Metronidazole on Peri-implantitis

Abstract:Objective To compare the clinical effects of topical minocycline ointment and oral metronidazole in the treatment of peri-implantitis. Methods 36 patients with peri-implantitis who came to our hospital from March 2016 to May 2018 were enrolled. After the treatment of the implants, the minocycline hydrochloride was randomly divided into three groups. Ointment group and oral metronidazole group, 18 cases in each group. The minocycline hydrochloride ointment group was treated with minocycline hydrochloride ointment and the oral metronidazole group was treated with oral metronidazole. Modified plaque index (mPLI), modified sulcus bleeding index (mSBI), and depth of probing (PD) parameters were compared at baseline, 4 weeks and 8 weeks after treatment.Results At 4 weeks and 8 weeks after treatment, mPLI, mSBI and PD parameters were lower than baseline in the two groups, the difference was statistically significant (P<0.05); The mPLI, mSBI and PD parameters at 4 and 8 weeks after treatment with minocycline hydrochloride ointment were lower than those in oral metronidazole group 4 weeks: mPLI (0.69±0.47) vs (1.46±0.33), mSBI (0.62±0.41) vs (1.16±0.38), PD (2.47±0.37) mm vs (3.52±0.54) mm; 8 weeks: mPLI (0.98±0.39) vs (1.52±0.30), mSBI (0.86±0.45) vs (1.26±) 0.43), PD (2.93±0.50) mm vs (3.46±0.46) mm], the difference was statistically significant (P<0.05).Conclusion Minocycline hydrochloride ointment and metronidazole have a definite curative effect on peri-implantitis. The effect of minocycline hydrochloride ointment is better than oral metronidazole. The topical drug can achieve short-term optimization.