盐酸米诺环素软膏治疗中重度慢性牙周炎的临床疗效

目的 探讨盐酸米诺环素软膏治疗中重度慢性牙周炎的临床疗效。方法 选取2017年2月~2019年3月我院口腔科收治的中重度慢性牙周炎患者136例，随机分为观察组和对照组，各68例。对照组予碘甘油治疗，观察组以盐酸米诺环素软膏治疗。比较两组出血指数（BI）、牙龈指数（GI）、探诊深度（PD）、牙齿松动度（TM）及临床效果。结果 观察组PD、BI、GI、TM分别为（2.31±0.21）mm、（0.78±0.23）分、（0.66±0.18）分、（0.17±0.08）mm，均低于对照组的（3.20±0.43）mm、（1.22±0.36）分、（1.37±0.37）分、（0.30±0.15）mm，差异有统计学意义（P＜0.05）；观察组治疗总有效率高于对照组，差异有统计学意义（P＜0.05）。结论 对中重度慢性牙周炎患者局部予以盐酸米诺环素软膏疗效显著，可有效降低患者牙龈出血及牙齿松动情况。

Clinical Efficacy of Minocycline Hydrochloride Ointment in the Treatment of Moderate to Severe Chronic Periodontitis

Abstract:Objective To investigate the clinical efficacy of minocycline hydrochloride ointment in the treatment of moderate to severe chronic periodontitis. Methods A total of 136 patients with moderate to severe chronic periodontitis admitted to our department from February 2017 to March 2019 were randomly divided into observation group and control group, 68 cases in each group. The control group was treated with iodine glycerol, and the observation group was treated with minocycline hydrochloride ointment. The bleeding index (BI), gingival index (GI), probing depth(PD), tooth mobility (TM) and clinical effects were compared between the two groups. Results The PD, BI, GI, and TM of the observation group were (2.31±0.21) mm, (0.78±0.23), (0.66±0.18), and (0.17±0.08) mm, respectively, which were lower than those of the control group (3.20±0.43)mm, (1.22±0.36), (1.37±0.37), (0.30±0.15) mm, the difference was statistically significant (P<0.05); the total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05).Conclusion The effect of minocycline hydrochloride ointment on patients with moderate to severe chronic periodontitis is significant, which can effectively reduce bleeding and tooth loosening in patients.