前列地尔联合缬沙坦对慢性肾小球肾炎患者肾功能指标的影响

目的 观察前列地尔联合缬沙坦治疗慢性肾小球肾炎对患者尿蛋白及肾功能指标的影响。方法 选择2017年5月~2019年4月在我院肾内科选取慢性肾小球肾炎患者78例，按照随机数字表法分为对照组和治疗组，各39例。对照组采用缬沙坦治疗，治疗组在对照组基础上联合前列地尔治疗。比较两组尿素氮（BUN）、血肌酐（Scr）、尿酸（UA）、24h尿蛋白定量及临床疗效。结果 治疗后两组BUN、Scr、UA与24h尿蛋白定量水平均低于治疗前，且治疗组低于对照组，差异有统计学意义（P＜0.05）；治疗组有效率高于对照组，差异有统计学意义（P＜0.05）。结论 前列地尔联合缬沙坦能有助于改善患者BUN、Scr、UA、24h尿蛋白定量水平，从而改善肾功能，提高临床疗效。

Effect of Alprostadil Combined with Valsartan on Renal Function Indexes in Patients with Chronic Glomerulonephritis

Objective To observe the effect of alprostadil combined with valsartan on urinary protein and renal function in patients with chronic glomerulonephritis. Methods From May 2017 to April 2019, 78 patients with chronic glomerulonephritis were enrolled in our Department of Nephrology. According to the random number table, they were divided into control group and treatment group, 39 cases each. The control group was treated with valsartan, and the treatment group was treated with alprostadil on the basis of the control group. The two groups were compared with urea nitrogen (BUN), serum creatinine (Scr), uric acid (UA), 24h urine protein and clinical efficacy. Results After treatment, the levels of BUN, Scr, UA and 24h urine protein were lower than those before treatment, and the treatment group was lower than the control group, the difference was statistically significant (P<0.05); the treatment group was more effective than the control group, the difference was statistically significant (P<0.05). Conclusion Alprostadil combined with valsartan can improve the quantitative levels of BUN, Scr, UA and 24h urine protein, thereby improving renal function and improving clinical efficacy.