我国成人阻塞性睡眠呼吸暂停低通气综合征患病率的Meta分析

目的 通过对我国2000~2017年阻塞性睡眠呼吸暂停低通气综合征流行病学研究的系统回顾，了解我国目前OSAHS整体患病率情况，为该病的科普及健康教育提供依据。方法 计算机检索中国知网数据库、万方数据库、中文科技期刊全文数据库、PubMed、Web of Science等中英文数据库，辅助参考文献追溯及特定文献检索，查找我国成人OSAHS流行病学调查。由2人进行独立检索，利用NoteExpress和Endnote x7文献管理软件进行文献梳理，通过逐步筛选评价，得到研究对象选取方法、诊断标准相同的14项研究，进行OSAHS患病率的Meta分析。结果 我国2000~2017年成人OSAHS总患病率为3.93%[95%CI（3.14%，4.73%）]。亚组分析显示:在性别上，男女OSAHS患病率分别为5.19%[95%CI（4.14%，7.23%）]、2.17%[95%CI（1.00%，3.34%）];各年龄段患病率分别为20~29岁为2.28%[95%CI（0.93%，3.63%）]、30~39岁为2.70%[95%CI（1.42%，3.97%）]、40~49岁为4.91%[95%CI（3.32%，6.50%）]、50~59岁为5.05%[95%CI（3.70%，6.40%）]、60~69岁为2.55%[95%CI（1.54%，3.56%）]。我国OSAHS患病率在性别、年龄存在差异，在研究发表时间未发现明显差异。结论 OSAHS为慢性源头性疾病，在未来的OSAHS流行病学调查中应关注合并症、个人体征、社会学信息与该疾病的相关关系，为进一步了解我国成人OSAHS流行病学分布情况提供依据。

Meta-analysis of the Prevalence of Adult Obstructive Sleep Apnea Hypopnea Syndrome in China

Objective To systematically review the epidemiological study of obstructive sleep apnea hypopnea syndrome in China from 2000 to 2017, to understand the current prevalence of OSAHS in China, and to provide evidence for the popularization of health education in the disease. Methods Computers searched Chinese Knowledge Network Database, Wanfang Database, Chinese Science and Technology Journal Full-text Database, PubMed, Web of Science and other Chinese and English databases, assisted reference traceability and specific literature search to find adult epidemiological survey of OSAHS in China. Two people conducted independent search, and used NoteExpress and Endnote x7 document management software to carry out literature combing. Through stepwise screening and evaluation, 14 research methods with the same research method and diagnostic criteria were obtained, and the meta-analysis of OSAHS prevalence was performed. Results The total prevalence of adult OSAHS in China from 2000 to 2017 was 3.93% [95% CI (3.14%, 4.73%)]. Subgroup analysis showed that the prevalence of OSAHS for men and women was 5.19% [95%CI (4.14%, 7.23%)], 2.17% [95%CI (1.00%, 3.34%)], respectively; the prevalence rates for each age group were 20~29 years old is 2.28% [95%CI (0.93%, 3.63%)], 30~39 years old is 2.70% [95%CI (1.42%, 3.97%)], 40~49 years old is 4.91% [95%CI (3.32%, 6.50) %)], 5.05% for 50~59 years old [95%CI (3.70%, 6.40%)], and 2.55% for 60~69 years old [95%CI (1.54%, 3.56%)]. The prevalence of OSAHS in China was different in gender and age, and no significant difference was found in the study publication time. Conclusion OSAHS is a chronic source disease. In the future OSAHS epidemiological survey, attention should be paid to the relationship between comorbidities, personal signs and sociological information and the disease, so as to provide a basis for further understanding the epidemiological distribution of adult OSAHS in China.