参附注射液对慢性阻塞性肺疾病的临床观察及其对免疫功能的影响

目的:探讨参附注射液对慢性阻塞性肺疾病的临床治疗效果及其对免疫反应的影响。方法: 筛选我院收治的符合标准的160 例病人，根据随机数字表法，随机分为对照组和试验组，对照组给予基础西医治疗，试验组在对照组相同的治疗基础上加参附注射液，治疗周期为14 d。根据临床症状评价疗效，同时采用免疫比浊法检测治疗前后血清中免疫球蛋白IgA、IgM、IgG的含量。利用流式细胞术检测T淋巴细胞亚群CD4、CD8的水平。结果: 和对照组比较，试验组的总有效率显著增加，疗效显著。参附注射液试验组可以增加血清中免疫球蛋白IgA、IgM、IgG的水平，差异显著。和对照组比较，试验组增加T淋巴细胞亚群CD4，降低了CD8的水平。结论: 参附注射液可以显著增加慢性阻塞性肺疾病的治疗效果，增加免疫球蛋白的表达，增强免疫功能。

Clinical observation of shenfu injection on chronic obstructive pulmonary disease and its effect on immune response

Objective: To investigate the clinical effect of shenfu injection on chronic obstructive pulmonary disease (COPD) and its effect on immune response. Methods: One hundred and sixty patients meeting the standard in our hospital were selected and randomly divided into control group and experimental group according to the random number table method. The control group was treated with basic western medicine. In the experimental group, shenfu injection was used in addition to basic treatment and the treatment period was 14 days. The efficacy was evaluated according to clinical symptoms. And the levels of immunoglobulin IgA, IgM and IgG in serum before and after treatment were detected by immunoturbidimetry. The levels of CD4 and CD8 of T lymphatic subsets were detected by flow cytometry. Results: Compared with the control group, the total effective rate and curative effect of the experimental group were significantly increased. In the experimental group of shenfu injection, IgA, IgM and IgG levels of immunoglobulin in serum were increased, with significant differences. The experimental group increased the T lymphatic subgroup CD4 and decreased the level of CD8. Conclusion: Shenfu injection may significantly increase the therapeutic effect of chronic obstructive pulmonary disease(COPD), increase the expression of immunoglobulin and enhance the immune function.