宫颈癌组织中Foxm1、ANGPTL4蛋白表达及临床意义

目的:探讨宫颈癌组织中Foxm1、ANGPTL4蛋白表达及临床意义。方法:选取2017年1月-2018年3月河南省人民医院保存的宫颈癌组织标本72例，同时选取正常宫颈组织标本35例作为对照组，采用免疫组化检测Foxm1、ANGPTL4蛋白表达水平。结果:宫颈癌组织Foxm1和ANGPTL4蛋白阳性表达率为63.89%和75.00%，明显高于对照组（P＜0.05）；FIGO分期Ⅱ期、肌层浸润≥1/2、中低分化宫颈癌Foxm1蛋白阳性表达率分别为89.47%、84.62%和79.07%，明显高于Ⅰ期、肌层浸润＜1/2、高分化患者（P＜0.05）；有脉管浸润宫颈癌ANGPTL4蛋白阳性表达率为95.24%，明显高于无脉管浸润（P＜0.05）；Foxm1与ANGPTL4蛋白表达呈正相关（rs=0.301，P＜0.05）。结论:宫颈癌组织中Foxm1、ANGPTL4蛋白呈高表达，在疾病发生发展中可能有重要作用。

Expression and clinical significance of Foxm1 and ANGPTL4 protein in cervical cancer tissues

Objective: To investigate the expression and clinical significance of Foxm1 and ANGPTL4 in cervical cancer. Methods:From January 2017 to March 2018, 72 specimens of cervical cancer and 35 specimens of normal cervical tissue were selected as controls; the expression of Foxm1 and ANGPTL4 protein was detected by immunohistochemical staining. Results: The positive rates of Foxm1 and ANGPTL4 protein in cervical cancer tissues were 63.89% and 75.00%, which were significantly higher than those in the control group(P< 0.05); The positive expression rates of Foxm1 protein in stage II, myometrial invasion ≥ 1/2， and moderately and poorly differentiated cervical cancer were 89.47%, 86.84% and 79.07% respectively, which were significantly higher than those in stage I, myometrial invasion <1/2 and well differentiated patients(P<0.05); The positive expression rate of ANGPTL4 protein in cervical carcinoma with vascular invasion was 95.24%, which was significantly higher than that without vascular invasion(P<0.05); We found a positive correlation between Foxm1 and ANGPTL4 protein expression(rs=0.301, P < 0.05). Conclusion: Foxm1 and ANGPTL4 proteins are highly expressed in cervical cancer tissues, and may play an important role in the development of diseases.