| 足细胞上皮间质转分化研究 |
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| 引用本文： | 崔方强.足细胞上皮间质转分化研究[J].医学信息,2019,0(22):21-23. |
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| 作者姓名： | 崔方强 |
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| 作者单位： | （首都医科大学附属北京中医医院肾病科，北京 100010） |
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| 摘 要： | 足细胞是肾小球滤过膜的重要组成部分，在维持肾小球正常滤过功能方面起着至关重要的作用。足细胞上皮间质转分化（EMT）是多种慢性肾脏疾病蛋白尿产生及疾病进展的重要病理机制。减轻足细胞EMT已经成为慢性肾脏疾病防治研究的热点。基于此，本文主要就足细胞的生理特点、EMT病理过程及相关信号通路作一综述。
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| 关 键 词： | 足细胞 上皮间质转分化 信号通路 慢性肾脏病 |
Epithelial Transdifferentiation of Podocytes |
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| CUI Fang-qiang.Epithelial Transdifferentiation of Podocytes[J].Medical Information,2019,0(22):21-23. |
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| Authors: | CUI Fang-qiang |
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| Institution: | (Department of Nephrology,Beijing Traditional Chinese Medicine Hospital,Capital Medical University,Beijing 100010,China) |
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| Abstract: | Podocytes are an important component of glomerular filtration membrane and play a vital role in maintaining normal glomerular filtration function. Epithelial mesenchymal transition (EMT) of podocytes is an important pathological mechanism for proteinuria production and disease progression in a variety of chronic kidney diseases. Reducing podocyte EMT has become a hot spot in the prevention and treatment of chronic kidney disease. Based on this, this paper reviews the physiological characteristics of podocytes, pathological processes of EMT and related signaling pathways. |
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| Keywords: | Podocytes Epithelial-mesenchymal transition Signaling pathway Chronic kidney disease |
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