| 液体活检在肿瘤监测管理中的应用 |
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| 引用本文： | 何文婷1,翟云兰2,张洪亮1. 液体活检在肿瘤监测管理中的应用[J]. 医学信息, 2019, 0(19): 29-31. DOI: 10.3969/j.issn.1006-1959.2019.19.010 |
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| 作者姓名： | 何文婷1 翟云兰2 张洪亮1 |
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| 作者单位： | （1.新疆维吾尔自治区中医医院肿瘤二科，新疆 乌鲁木齐 830000；2.北京吉因加科技有限公司，北京 102200） |
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| 摘 要： | 目前临床在诊疗过程中，无活检组织样本的情况下，常规使用液体活检检测肿瘤敏感靶点以寻找敏感靶向药。而最新研究中液体活检计算的肿瘤突变负荷（bTMB）可以对PD-1/L1抑制剂进行疗效预测；同时越来越多的研究发现液体活检可以通过对肿瘤分子负荷进行检测分析，用于肿瘤的预后评估，微小残留病灶监测，以及肿瘤的克隆进化分析，这使得液体活检有望在肿瘤诊疗过程中辅助临床进行更全面的监测管理，本文就此做一综述。
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| 关 键 词： | 液体活检 肿瘤 ctDNA 液体监测 |
Application of Liquid Biopsy in Tumor Monitoring and Management |
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| HE Wen-ting1,ZHAI Yun-lan2,ZHANG Hong-liang1. Application of Liquid Biopsy in Tumor Monitoring and Management[J]. Medical Information, 2019, 0(19): 29-31. DOI: 10.3969/j.issn.1006-1959.2019.19.010 |
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| Authors: | HE Wen-ting1 ZHAI Yun-lan2 ZHANG Hong-liang1 |
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| Affiliation: | (1.Department of tumor,Subject Two,Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine,Urumqi 830000,Xinjiang,China;2.Beijing Jiyinjia Technology Co.,Ltd.,Beijing 102200,China) |
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| Abstract: | At present, in the clinical diagnosis and treatment process, without biopsy tissue samples, routine use of liquid biopsy to detect tumor-sensitive targets to find sensitive targeted drugs. The tumor mutation load (bTMB) calculated by liquid biopsy in the latest study can predict the efficacy of PD-1/L1 inhibitors. At the same time, more and more studies have found that liquid biopsy can be used for tumor analysis by analyzing tumor molecular load. Prognostic assessment, micro-residual lesion monitoring, and clonal evolution analysis of tumors make liquid biopsy promising for more comprehensive monitoring and management during tumor diagnosis and treatment. This article reviews this issue. |
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| Keywords: | Liquid biopsy Tumor ctDNA Fluid monitoring |
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