18F-FDG PET/CT在结直肠癌术后预后中的应用

目的:探讨18F-脱氧葡萄糖（FDG）PET/CT在结直肠癌术后预后中的应用价值。方法:回顾性分析行PET/CT检查后进行手术切除且资料完整的73例结直肠癌患者，研究PET/CT代谢参数与其术后预后的关系。结果:结直肠癌区域淋巴结转移阳性者原发灶MTV明显高于阴性者，其预测淋巴结转移的最佳截断值为7.39。SUVmax、SUVmean、SUVpeak、MTV及TLG预测预后的最佳截断值分别为14.80、8.62、13.62、11.55及219.27。Cox单因素回归分析显示肿瘤的长径、N分期、M分期、MTV及TLG与预后有关，多因素分析显示M分期及MTV是预后的独立危险因素。Kaplan-Meier生存分析表明MTV≤11.55、TLG≤219.27的患者无进展生存期明显延长。结论:PET/CT在结直肠癌术后预后中具有应用价值，MTV、TLG能在一定程度上反映患者术后的预后情况。

The application of 18F-FDG PET/CT in the prognosis of postoperative colorectal cancer

Objective: To investigate the value of 18F-FDG PET/CT in the prognosis of postoperative colorectal cancer. Methods: A retrospective analysis was established by enrolling 73 colorectal cancer patients who underwent surgery after PET/CT examination.They all had complete data. The relationship between metabolic parameters and prognosis was studied. Results: MTV in colorectal cancer with lymph node metastasis were significantly higher than those with negative results,and the best cut-off value in predicting lymph node metastasis was 7.39.The best cut-off values for SUVmax, SUVmean, SUVpeak, MTV and TLG in predicting prognosis were respectively 14.80, 8.62, 13.62, 11.55 and 219.27. Univariate Cox regression analysis showed that tumor length, N stage, M stage, MTV and TLG were related to prognosis and multivariate analysis showed that M stage and MTV were independent risk factors. Kaplan-Meier survival analysis showed that progression free survival of patients with MTV ≤11.55 and TLG≤219.27 were significantly prolonged. Conclusion: PET/CT may have application value in the prognosis of colorectal cancer after surgery. MTV and TLG can reflect the prognosis of patients after operation.