铁代谢与2型糖尿病的相关性研究

目的 探讨铁代谢与2型糖尿病相关性。方法 选取2016年4月~2018年2月我院收治的2型糖尿病患者45例设为观察组；另选同期入院健康体检者42例设为对照组。均采集空腹静脉血5 ml，采用全自动生化分析仪测定血清铁、转铁蛋白（TRF）、铁蛋白（SF）、运铁蛋白饱和度（TS）；采用生化检测测定空腹血糖（FBG）、糖化血红蛋白（HbAlc）；采用SPSS Pearson相关性分析软件分析2型糖尿病与铁代谢关系。结果 观察组患者血清铁（7.34±1.21）μmol/L、TRF（7.10±1.22）g/L、SF（119.28±12.15）μg/L、TS（33.55±4.56）%、FBG（10.52±1.29）mmol/L及HbAlc（9.73±1.25）%的表达分别高于对照组的（4.53±0.95）μmol/L、（0.55±0.12）g/L、（102.42±10.93）μg/L、（23.21±3.29）%、（5.98±0.74）mmol/L（6.12±0.93）%，差异有统计学意义（P＜0.05）；Pearson相关性分析，2型糖尿病与血清铁、TRF、SF及TS表达均呈正相关（P＜0.05）。结论 铁代谢指标对2型糖尿病的发生发展可能存在促进关系，因此加强铁代谢测定能为2型糖尿病诊疗提供依据和参考。

Correlation between Iron Metabolism and Type 2 Diabetes

Objective To investigate the relationship between iron metabolism and type 2 diabetes.Methods 45 patients with type 2 diabetes admitted to our hospital from April 2016 to February 2018 were enrolled in the observation group.42 patients who were admitted to the hospital for the same period were selected as the control group.5 ml of fasting venous blood was collected, and serum iron, transferrin(TRF),ferritin(SF),and transferrin saturation(TS)were measured by automatic biochemical analyzer.Fasting blood glucose(FBG) was determined by biochemical test.Glycated hemoglobin (HbAlc);SPSS Pearson correlation analysis software was used to analyze the relationship between type 2 diabetes and iron metabolism.Results In the observation group,serum iron (7.34±1.21) μmol/L,TRF(7.10±1.22)g/L,SF(119.28±12.15) μg/L,TS(33.55±4.56)%,FBG(10.52±1.29) mmol,the expressions of /L and HbAlc (9.73±1.25)% were higher than those of the control group (4.53±0.95) μmol/L,(0.55±0.12) g/L,(102.42±10.93) μg/L,(23.21±3.29)%, (5.98±0.74) mmol/L(6.12±0.93)%,the difference was statistically significant(P<0.05);Pearson correlation analysis,type 2 diabetes was positively correlated with serum iron,TRF,SF and TS expression(P<0.05).Conclusion Iron metabolism index may promote the development of type 2 diabetes. Therefore, the determination of iron metabolism can provide a basis and reference for the diagnosis and treatment of type 2 diabetes.