Nano-CuO inhibited voltage-gated sodium current of hippocampal CA1 neurons via reactive oxygen species but independent from G-proteins pathway |
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| Authors: | Liu Zhaowei Liu Shichang Ren Guogang Zhang Tao Yang Zhuo |
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| Affiliation: | College of Medicine, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, China. |
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| Abstract: | The aim of this study was to investigate the effects of nano-CuO on voltage-gated sodium current (I(Na) ) in hippocampal CA1 neurons. The results suggested that nano-CuO inhibited amplitudes of I(Na) currents and prolonged peak rise time of action potential (AP). The responses to nano-CuO were inhibited by reactive oxygen species (ROS) scavenger. However, the G-proteins inhibitor did not block the effects of nano-CuO. The effects of nano-CuO were mediated through activation of ROS-I(Na) -AP signaling cascades and independent from G-proteins pathway. |
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| Keywords: | nano‐CuO voltage‐gated sodium current hippocampus reactive oxygen species |
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