基于抗氧化机制的中药及化学成分在骨质疏松中的应用

目前，氧化应激在骨质疏松发病中的地位日益突出。研究发现高水平的活性氧（ROS）及相关氧化产物的蓄积可打破骨代谢平衡，造成骨质疏松症的发生。近年来，中药及其化学成分通过改善氧化应激防治骨质疏松的研究日益增多，并取得较多进展。本文在对氧化应激与骨质疏松症关系进行总结基础上，对常见中药及其抗氧化化学成分，如黄酮类、多酚类、皂苷类等经由抗氧化应激机制，防治骨质疏松症的研究做出简要综述，以期为临床应用、新药研发等提供借鉴。

Review on Application in Osteoporosis of Chinese Materia Medica and Chemicals Based on Antioxidant Mechanism

At present, oxidative stress plays an increasingly prominent role in the pathogenesis of osteoporosis. It has been found that high level of reactive oxygen species (ROS) and the accumulation of related oxidation products can break the dynamic balance of bone metabolism, which leads to the occurrence of osteoporosis. In recent years, the research of Chinese materia medica and its chemicals on preventing osteoporosis through alleviating oxidative stress is increasing, and some achievements have been obtained. In this paper, the pathogenesis of osteoporosis mediated by oxidative stress was briefly reviewed by referring to relevant literature, and the research and application of TCM and its antioxidant chemicals, such as flavonoids, polyphenols and saponins on osteoporosis were also introduced, which may provide reference for chinese materia medica clinic use, research and development of new drug, etc.