LIVER RESECTION FOR METASTASES FROM COLORECTAL CANCER |
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| Authors: | HG MUKHOPADHYAY LS VOHRA AK SHARMA R SOLANKI PS REDDY GS CHOPRA P SUBHAS |
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| Affiliation: | 1. Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea;2. Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea;3. Department of Surgery, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea;1. CSIR-National Botanical Research Institute, Council of Scientific and Industrial Research (CSIR-NBRI), Rana Pratap Marg, Lucknow, 226 001, India;2. Centre of Bio-Medical Research (CBMR), Sanjay Gandhi Post-Graduate Institute of Medical Sciences Campus, Raibareli Road, Lucknow, 226014, India;3. Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, 2 Rafi Marg, New Delhi, 110 001, India;1. Section of Interventional Radiology, Fred Hutchinson Cancer Research Center, University of Washington, Box 357115, 1959 NE Pacific Street, Seattle, WA 98119;2. Department of Radiology, and Department of Medical Oncology, Fred Hutchinson Cancer Research Center, University of Washington, Box 357115, 1959 NE Pacific Street, Seattle, WA 98195.;1. Department of Physics, University of Surrey, Guildford, Surrey GU2 7XH, UK;2. Radioactivity Group, National Physical Laboratory, Teddington TW11 0LW, UK;3. Medical Physics Department, Royal Surrey County Hospital, Guildford, Surrey, GU2 7XX, UK |
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| Abstract: | Five percent of patients with liver secondaries from colorectal carcinoma are potentially resectable and several studies have demonstrated significantly improved survival following resection. Two hundred and ten patients operated for colorectal carcinoma were followed up. Computed tomography confirmed potentially resectable metastasis to the liver in 38. On exploration 18 patients who had 4 or less hepatic metastases and no extrahepatic disease, underwent resection of their secondaries. Fourteen were males and 4 females with a mean age of 43.5 (SD 13.6, range 18-72) years. Ten patients presented with synchronous liver metastasis and 8 had metachronous disease. There was no post-operative mortality. All 18 have been followed up. for a median period of 23.5 (range 12-38) months. Seven patients are alive and well with no evidence of recurrence at a median period of 28 months (survival 39%). Four are alive with local recurrence in the liver. Median time to recurrence was 22 months. Seven patients have died of disseminated disease. The disease free survival at 28 months is 39% and the overall survival 61%. A close follow-up protocol for all patient undergoing curative surgery for colorectal cancer is essential, if such patients are to be selected early.KEY WORDS: Colorectal cancer, Liver resection, Metastases |
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| Keywords: | Colorectal cancer Liver resection Metastases |
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