Use of recrystallized lactose as carrier for inhalation powder of interferon a2b

The aim of the present investigation was to evaluate the effects of physical properties of the carrier on the in vitro deposition performance of dry powder inhalations (DPIs) of recombination human interferon a2b (IFN a2b). Recrystallized lactose was used as the carrier. Inverse gas chromatography (IGC) was used to assess the surface energy, and atomic force microscopy (AFM) was used to assess the roughness and topography of the carrier. In vitro performance of the powder blends was strongly correlated to the physical properties of the carrier. Plotting emitted dose (%) vs. flow rate and fine particle fraction vs. surface energy, yielded an R2 value of 0.9621 and 0.9146, respectively.