Pharmacokinetics of theophylline before and after nephrectomy in dogs |
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Authors: | R E Brashear P Veng-Pedersen M D Karol |
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Affiliation: | Indiana University School of Medicine, Indianapolis. |
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Abstract: | The role of the kidneys in the elimination of theophylline was directly assessed using nephrectomized dogs. Data was analyzed by two different pharmacokinetic approaches. Analysis indicated that a given dosage regimen produced significantly different serum concentrations before and after nephrectomy. Model independent pharmacokinetic analysis failed to show a significant difference in parameters. A model dependent approach, using a nonlinear regression analysis employing a linear two-compartment model, demonstrated that the differences observed could be accounted for by a change in the first order elimination kinetics. |
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Keywords: | Nephrectomy Theophylline |
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