白癜风患者血浆三种神经肽测定及其临床意义

目的：β内啡肽（β－EP）、神经肽Y（NPY）及降钙素基因相关肽（CGRP）是重要的神经递质，同时也可作为免疫调节因子发挥作用。本研究旨在观察这些神经肽是否可能与白癜风的发病有关。方法：用放射免疫分析法测定40例白癜风处于进展期或稳定期的不同类型患者血浆3种神经肽浓度，并与23例正常对照作比较。结果：寻常型（局限性与泛发性）、节段型、进展期和稳定期白癜风患者血浆β－EP、NPY水平均较正常对照组显著增高；进展期白癜风NPY比稳定期显著提高；泛发性及进展期白癜风血浆CGRP比正常对照组显著增高。结论：结果表明上述三种神经肽与白癜风的发病可能存在一定关系，开发神经肽拮抗剂对于白癜风的治疗可能成为一种新的途径。

Detection of Some Plasma Neuropeptides and Its Clinical Significance in Patients with Vitiligo

Objective To investigate the relationship between beta endorphin (3 - EP), neuropeptide Y (NPY) and calcitonin gene- related peptide (CGRP) and the pathogenesis of vitiligo. Methods Radioimmunoassay (RIA) was employed to detect the plasma levels of three neuropeptides in 40 patients with various types of vitiligo and in 23 normal controls. Results The plasma levels of both 3 - EP and NPY in vitiligo pateints were significantly higher than those in normal controls. The plasma level of NPY in progressive vitiligo was significantly higher than that in stable one. The plasma level of CGRP in generalized and progressive vitiligo was significantly increased when compared with normal controls. Conclusion These findings indicate that the three mentioned neuropeptides may play a role in the pathogenesis of vitiligo.