卡托普利注射液对充血性心力衰竭细胞因子的干预作用

目的　探讨血管紧张素转换酶抑制剂 (ACEI)对心力衰竭 (CHF)患者血清肿瘤坏死因子 -α(TNF-α) ,白细胞介素 - 6 (IL- 6 ) ,白细胞介素 - 10 (IL- 10 ) ,一氧化氮 (NO)的干预影响。方法　将 5 5例 CHF患者分为治疗组和常规组。常规组采用常规治疗 ,治疗组在常规治疗基础上用卡托普利注射液治疗 1周 ,在治疗前与治疗后测定 TNF-α,IL- 6 ,IL- 10 ,NO的变化。结果　治疗后两组血清 TNF- α,IL- 6 ,NO水平均明显下降 (P<0 .0 5 ,P<0 .0 1,P<0 .0 1) ;治疗前血清 IL - 10水平较对照组升高无显著性差异 (P>0 .0 5 ) ,治疗后 IL - 10水平明显升高 (P<0 .0 5 ) ;治疗组治疗后上述指标降低或升高的幅度显著高于常规组治疗后降低或升高的幅度 (P<0 .0 5 )。结论　 ACEI可能通过调控细胞因子的浓度来改善心功能 ,为其治疗心力衰竭进一步提供理论依据

The intervention action of Captopril on the serum cytokine levels in patients with congestive heart failure

Objective To investigate the intetrvention action of captopril on the serum cytokine levels in patients with congestive heart failure.Method 55 patients with congestive heart failure were randomized into routine group(n=22)and captopril group(n=23).Routine group received routine treatment,and Captopril group were treated with roution therapy plus captopril intravenously for 7 days. Before and after treatment the serum tumour necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),nitric oxide(NO) were determined.Result After the treatment the levels of TNF-α,IL-6,NO were significantly lower than that before the treatment(P<0.05,P <0.01,P<0.01)in the routine group and Captopril group.Before treatment the serum IL-10 levels in these too group was higher than the control,but no statistic significant difference(P>0.05).After the treatment the serum IL-10 was significantly higher than that before treatment (P<0.05).The decreacing and increasing degrees of the indices were more significantly in the Captopril group than in the routine group.Conclution The cardiac function can be improved by ACEI by ways of adjusting the concentrations of the cytokines,the conclusion provid another proof for using ACEI.