2009年北京市大兴区健康人群甲型H1N1流感抗体水平监测及接种甲型H1N1流感疫苗免疫效果

目的了解人群甲型H1N1流感抗体水平及甲型H1N1流感疫苗的免疫效果,为甲型H1N1流感疫苗的科学使用提供依据。方法选择北京市大兴区庞各庄镇、安定镇、黄村镇、亦庄镇和兴丰街道5个地区各年龄组共200人作为人群抗体监测对象,其中各年龄组共选择50人作为免疫效果评估对象,抽取静脉血250份,采用血凝抑制实验方法测定HI抗体。结果 200人中抗体阳性者48人,阳性率为24%,几何平均滴度(GMT)为1:80.25,不同性别、地区人群的HI抗体阳性率差异无统计学意义。10～20岁和60岁以上组人群抗体阳性率最高,分别为42%和40%。监测免疫后人群50人,免疫成功率为92%,GMT是免疫前的8.7倍。结论大兴区已有24%的人群具有甲型H1N1流感保护性抗体;甲型H1N1流感疫苗具有良好的流行病学保护效果。

Antibody levels of Influenza A(H1N1)and the immunization effects of vaccine among healthy people in Daxing in 2009

Objective To understand the antibody levels of influenza A（H1N1） among healthy people and the immunization effects of H1N1 vaccine,and to offer scientific basis for using vaccine.Methods 200 subjects were randomly selected among various age groups from PangGeZhang town,AnDing town,HangCun town,YiZhuang town and XingFeng Street.And 50 people were selected from all age groups as immune effect evaluation subjects.Totally 250 serum samples were collected to detect the hemagglutination-inhibition （HI） antibody against influenza A （H1N1） 2009 virus.Results Among the 200 participates in this survey,48 showed positive HI antibody to this pandemic virus,the sero-positivie rate was 24%,and GMT was 1：80.25.There were no significant differences on the sero-positivity between different sex and places.The age group of 10 ～20 years old and aged 60 and over have the highest protective antibody positive rates,which were 42% and 40%,respectively.50 subjects were once vaccinated by the vaccine,their immune successful rate was 92% and the GMT increased by 8.7 times compared with before vaccination.Conclusion Conclusion More than 24% of the population in Daxing showed protective antibody against influenza A（H1N1） 2009 virus.The vaccine demonstrated a good epidemiological effect.