Valproic acid serum levels and protection against kindled amygdaloid seizures in the rat

Valproic acid has been reported to be very effective against kindled amygdaloid Scizures in several species. In this study, the anticonvulsant effectiveness of valproic acid against kindled amygdaloid Scizures was studied in a systematic, multiple-dose evaluation in rats. A correlation at 30 min. between the degree of Scizure protection and increased serum levels of valproic acid was seen. At 30 min., the fifty percent effective dose (ED₅₀) was found to be 200 mg/kg. Additionally, the fifty percent effective serum level (ESL₅₀) was estimated to be 500 mg/L.