长叶胡颓子降血糖、血脂及抗脂质过氧化作用的研究

目的研究长叶胡颓子果实降血糖、血脂及抗脂质过氧化作用并探讨其药理作用机制.方法以高胆固醇高脂饲料诱发高脂模型大鼠,四氧嘧啶致糖尿病小鼠,应用长叶胡颓子果实水煎液进行实验观察.检测空腹血糖(FBG)、血清胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、胰岛素(INS)、C肽(C-P)及血清脂质过氧化产物丙二醛(MDA)、活性氧(ROS)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-PX)水平.结果长叶胡颓子果实具有抑制高脂血症大鼠TC、TG、LDL-C的升高,降低ROS、MDA,增强SOD、CAT、GSH-PX活力的作用(P＜0.05),可使糖疗病小鼠FBG降低(P＜0.05),对血浆INS和C-P无影响,但胰岛素敏感指数(ISI)明显高于实验对照组(P＜0.05).结论长叶胡颓子果实具有降血糖、血脂和抗脂质过氧化作用,对心血管系统疾病、糖尿病有预防保健作用.

Effect of elaeagnus bockii diels on lowering serum lipid,glucose and anti-lipid peroxidation

Aim To study the effect and mechanism of elaeagnus bockii diels on lowering serum lipid,glucose and anti-lipid peroxidation.Methods The level of serum FBG,TC,TG,HDL-C,LDL-C,INS, C-Peptide,MDA,ROS,SOD,CAT and GSH-PX were observed in high-lipid-feed-induced-high-serum-lipid rats and alloxan induced diabetic mice after fed with elaeagnus bockii diels.Results Elaeagnus bockii diels could obviously inhibit rise of serum TC,TG and LDL-C on high lipid rats and could lower ROS and MDA ,improve the activity of SOD,CAT and GSH-PX ,lower FBG in diabetic mice.But elaeagnus bockii diels did not affect the quality of insulin and C-P in diabetic mice.ISI is obvious higher than that in control group.Conclusions Elaeagnus bockii diels has the effect of reducing serum lipid,glucose and anti-lipid peroxidation.It can prevent cardiovascular disease and diabetes.