HPLC法测定五维葡钙口服溶液中四组份的含量 |
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引用本文: | 申颖,陈国章.HPLC法测定五维葡钙口服溶液中四组份的含量[J].中国药品标准,2011,12(6):427-429. |
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作者姓名: | 申颖 陈国章 |
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作者单位: | 湖南省衡阳市药品检验所,衡阳,421001 |
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摘 要: | 目的:建立HPLC法同时测定五维葡钙口服溶液中维生素B1,维生素B2,维生素B6(以下简称VB1,VB2,VB6)和烟酰胺的含量.方法:采用C18柱;以0.005 mol·L-1己烷磺酸钠与0.008 mol·L-1庚烷磺酸钠的1%乙酸溶液-甲醇(74:26)为流动相;检测波长276 nm;流速:1.0 mL· min-1.结果:VB1在36.30~84.70 μg·mL-1;VB2在7.26~ 16.94 μg·mL-1;VB6在10.93~25.51μg·mL-1与烟酰胺在36.20~84.48 μg·mL -1的范围内峰面积与浓度具有良好线性关系;VB1,VB2,VB6与烟酰胺的回收率依次为:99.78%,RSD=1.58%(n=6);99.80%,RSD=1.22% (n =6);100.07%,RSD=0.75% (n=6);99.62%,RSD=1.01% (n =6).结论:该方法准确,灵敏度高,重现性好.
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关 键 词: | 高效液相色谱法 五维葡钙口服溶液 维生素B1、维生素B2、维生素B6 烟酰胺 含量 |
Determination of the Content of Four components in Five Vitamins and Calcium Gluconate Oral Solution by HPLC |
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Authors: | Shen Ying and Chen Guo-zhang |
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Institution: | (Hengyang Institute for Drug Control,Hengyang 421001 ) |
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Abstract: | Objective:To establish an HPLC method for the determination of Vitamin Bj, Vitamin B2, Vitamin B6 and Nicotinamide in Five Vitamins and Calcium Gluconate Oral Solution. Methods: Column:Shimadzu Cis; Mobile phase: 1% acetic acid solution of 0. 005 mol ·L^-1 Hexanesulfonic acid Sodium and 0. 008 mol · L^-1 Heptanesulfonic acid Sodium-methanol (74: 26) ; Detective wavelength: 276nm; Flow rate: 1.0 mL · min^-1. Results:The calibration curve was linear in the range of 36. 30 -84. 70μg ·mL^-1, 7.26 - 16. 94 μg · mL-1, 10. 93 -25. 51 μg·mL^-1, 36. 20 -84. 48 μg·mL^-1 for Vitamin Bj, Vitamin B2, Vitamin B6 and Nicotinamide; The recovery rate of Vitamin B~ , Vitamin B2, Vitamin B6 and Nieotinamide was 99.78%, RSD 1.58% (n =6) ; 99. 80%, RSD 1.22% (n =6) ; with 100. 07%, RSD O. 75% (n =6) ; 99.62%, RSD 1.01% (n =6). Conclusion:The method is simple, quick, accurate and reliable. |
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Keywords: | HPLC Five Vitamins and Calcium Gluconate Oral Solution Vitamin B1 Vitamin B2 Vitamin B6 Nicotinamide Assay |
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