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左乙拉西坦致皮疹2例
引用本文:张夏婷,刘刚,孙伟.左乙拉西坦致皮疹2例[J].药物不良反应杂志,2011,13(6):391-392.
作者姓名:张夏婷  刘刚  孙伟
作者单位:首都医科大学宣武医院神经内科,北京,100053
摘    要:2例女性癫痫患者(例1 15岁,例2 54岁),服用传统抗癫痫药物效果不佳,给予口服左乙拉西坦0.25 g2,次/d,分别在治疗第75、天,四肢及躯干部皮肤出现红色斑疹伴瘙痒。考虑皮疹与左乙拉西坦有关。例1停用左乙拉西坦后3 d皮疹消褪。例2停用左乙拉西坦并接受氯雷他定10 mg、1次/d治疗,1周后皮疹消褪。

关 键 词:左乙拉西坦  皮疹

Two cases of skin rash to levetiracetam
Zhang Xiating , Liu Gang , Sun Wei.Two cases of skin rash to levetiracetam[J].Adverse Drug Reactions Journal,2011,13(6):391-392.
Authors:Zhang Xiating  Liu Gang  Sun Wei
Institution:(Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)
Abstract:Two female patients with epilepsy,aged 15 and 54 years,received traditional antiepileptic drugs without good response,and then received oral levetiracetam 0.25 g twice daily,on days 5 and 7 of treatment,they developed red maculopapular rash with pruritus on their extremities and trunk,respectively.The rash was considered to be associated with levetiracetam.The rash of patient 1 subsided on day 3 after levetiracetam withdrawal.The rash of patient 2 disappeared after discontinuation of levetiracetam and receiving loratadine 10 mg once daily for one week.
Keywords:levetiracetam  skin rash
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