| 四氯化碳肝纤维化大鼠的Ⅳ型胶原水平和超微结构的动态变化 |
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| 引用本文： | 黎俏梅,孟辉,黄真炎,徐勤.四氯化碳肝纤维化大鼠的Ⅳ型胶原水平和超微结构的动态变化[J].安徽中医学院学报,2005,24(2):26-29. |
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| 作者姓名： | 黎俏梅 孟辉 黄真炎 徐勤 |
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| 作者单位： | 暨南大学医学院,广东,广州,510632;广州中医药大学基础医学院 |
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| 基金项目： | 国家中医药管理局科研项目;97A06; |
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| 摘 要： | 目的：观察四氯化碳(CCl4)致肝纤维化大鼠的Ⅳ型胶原水平和超微结构的动态变化。方法：采用CCl4后腿皮下注射复制大鼠肝纤维化模型。结果：模型组大鼠病理片呈肝纤维化变，贮脂细胞增生活跃，有较大量的Ⅳ型胶原沉积。超微结构可见大量的胶原纤维生成和成纤维细胞。结论：CCl4肝纤维化大鼠3周的胶原沉积量并不高，6周起胶原纤维沉积量逐渐增大，并向肝细胞延伸。从9周开始分割肝小叶，在第12周已有假小叶生成。
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| 关 键 词： | 肝纤维化 Ⅳ型胶原 超微结构 四氯化碳 |
| 文章编号： | 1000-2219(2005)02-0026-04 |
| 修稿时间： | 2004年11月30日 |
Observation on the Deposit of IV-collagen and Ultrastructure of Liver in Rats with Hepatic Fibrosis |
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| LI Qiao-mei,MENG Hui,HUANG Zhen-yan,XU Qin.Observation on the Deposit of IV-collagen and Ultrastructure of Liver in Rats with Hepatic Fibrosis[J].Journal of Anhui Traditional Chinese Medical College,2005,24(2):26-29. |
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| Authors: | LI Qiao-mei MENG Hui HUANG Zhen-yan XU Qin |
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| Abstract: | Objective: To observe the deposit of IV-collagen and ultrastructure of liver in rats with hepaticfibrosis in a dynamic state. Method: The fibrosis liver model was set up by hypodermic injection of carbon tetrachloride. Result : Hepaticfibrosis appeared,fat-storing cells( FSCs) actively proliferated and the deposit of IV-collagen gradually increased in rat liver. Under electro microscope ,A great quantity collagerous fibers and many FSCs were found out. Conclusion : Hepaticfibrosis result from CCl 4 is a gradual course. The deposit of IV-collagen obviously increases in 6th week, and gradually extents to liver cells. Hepatic lobules separated by collagerous fibers in 9th week, and pseudolobuli formed in 12th week. |
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| Keywords: | Fibrosis liver IV-collagen Ultrastructure Carbon tetrachloride |
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