Noradrenaline release from slices of the thalamus of normal and morphine-dependent rats |
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Authors: | M E Brodie R Laverty E G McQueen |
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Institution: | (1) MRC Toxicology Research Unit, University of Otago Medical School, P.O. Box 913, Dunedin, New Zealand;(2) Department of Pharmacology, University of Otago Medical School, P.O. Box 913, Dunedin, New Zealand |
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Abstract: | Summary The effect of morphine on potassium-induced stimulation of (3H)-noradrenaline release from slices of the rat thalamus was investigated. The in vitro addition of morphine (10–6 M) significantly depressed potassium-induced tritium overflow by 42% and this was prevented by the prior addition of naloxone (3×10–6 M) to the medium. The stimulation-evoked overflow of tritium from slices of the thalamus of morphine-dependent rats was not significantly different from normal controls. Addition of naloxone (10–5 M) 10 min before exposure of the tissues to 20 mM K+ significantly enhanced noradrenaline release from dependent slices. The results suggest that the basic release mechanism may have adapted to the continuous presynaptic inhibition of release by morphine. |
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Keywords: | Morphine withdrawal Noradrenaline release Thalamus Brain slices |
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